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Links from GEO DataSets

Items: 20

1.

Ly6C monocyte subsets transcriptome analysis from wild type and hyperhomocysteinemic mice

(Submitter supplied) Murine monocytes (MC) are classified into Ly6Chigh and Ly6Clow MC. Ly6Chigh MC is the pro-inflammatory subset and the counterpart of human CD14++CD16+ intermediate MC which contributes to systemic and tissue inflammation in various metabolic disorders, including hyperhomocysteinemia (HHcy). This study aims to explore molecule signaling mediating MC subset differentiation in HHcy and control mice.Mouse white blood cell were prepared from peripheral blood and stained with antibody against CD11b, Ly6G and Ly6C and subjected for flow cytometry cell sorting. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL21103 GPL19057
8 Samples
Download data: H5, JSON, TSV
Series
Accession:
GSE165879
ID:
200165879
2.

Ly6C monocyte subsets transcriptome analysis from control and ApoE-/- mice

(Submitter supplied) Inflammatory monocyte (MC) subset differentiation is a major feature in tissue inflammatory and atherosclerosis. The underlying molecular mechanism remains unclear. This study aims to explore molecule targets and signaling which determinate immunological features in MC subsets. ApoE-/- mice were fed a normal chow diet and switched to a high-fat (HF) diet at age 8 weeks and maintained on a HF diet for 12-14 weeks. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL19057 GPL21103
8 Samples
Download data: TAR
Series
Accession:
GSE189097
ID:
200189097
3.

Suppressor of cytokine signaling 1 is involved in gene regulation which control the survival of Ly6Clow monocytes in mice

(Submitter supplied) Objective: Monocytes are crucially involved in inflammatory processes. In mice, different subsets of monocytes can be distinguished by the expression of Ly6C, a surface marker that is highly expressed on inflammatory monocytes (Ly6C high) and to a lesser extent on patrolling monocytes (Ly6C low). Our previous study revealed an aggravated accumulation of inflammatory Ly6C high monocytes in atherosclerotic-prone mice bearing a deficiency in suppressor of cytokine signaling (Socs)-1. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL18752
33 Samples
Download data: IDAT, TXT
Series
Accession:
GSE103705
ID:
200103705
4.

Genomic characterization of murine monocytes reveals C/EBPb dependence of Ly6C-cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platform:
GPL19057
96 Samples
Download data: BIGWIG, TXT
Series
Accession:
GSE95702
ID:
200095702
5.

Genomic characterization of murine monocytes reveals C/EBPb dependence of Ly6C-cells [Single Cell RNA sequence]

(Submitter supplied) Single cell RNA sequencing of murine circulating blood monocytes under steady state conditions. 2 plates of cx3cr1-cre:rosa26YFP monocytes and 4 plates (3 plates total monocytes and 1 plate Ly6Cint monocytes) were pre-enriched by CD115-biotin MACS and afterwards FACS sorted.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
6 Samples
Download data: TXT
Series
Accession:
GSE95701
ID:
200095701
6.

Genomic characterization of murine monocytes reveals C/EBPb dependence of Ly6C-cells [RNA sequence]

(Submitter supplied) We show that monocyte development is accompanied by stepwise RNA expression changes and that Ly6C+ monocytes upon transfer develop into Ly6C- monocytes indicated by a comparable expression profile to host Ly6C- monocytes
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
67 Samples
Download data: TXT
Series
Accession:
GSE95411
ID:
200095411
7.

Genomic characterization of murine monocytes reveals C/EBPb dependence of Ly6C-cells [ChIP data]

(Submitter supplied) Chromatin status of murine blood Ly6C+ and Ly6C- monocytes indicates that both population share K4me3 marks (promoters) while Ly6C- monocytes establish de novo enhancers (K4me1, K4me2) during differentiation
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL19057
17 Samples
Download data: BIGWIG
Series
Accession:
GSE95409
ID:
200095409
8.

Genomic characterization of murine monocytes reveals C/EBPb dependence of Ly6C-cells [ATAC data]

(Submitter supplied) Analysis of open chromatin by ATAC sequencing in murine blood monocyte subsets
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL19057
6 Samples
Download data: BIGWIG
Series
Accession:
GSE95408
ID:
200095408
9.

Heterogeneity of Ly6G+Ly6C+ myeloid-derived suppressor cell (MDSC) infiltrates during S. aureus biofilm infection

(Submitter supplied) The two immune cell populations Myeloid-derived suppressor cells (MDSCs), monocytes (MONO) and neutrophils (PMNs) are difficult to differentiate because of shared surface marker expression. Here we utilize the integrin receptor CD11b combined with conventional Ly6G and Ly6C expression to more accurately separate cellular populations via FACS. Then we apply high-throughput RNA Sequencing to Ly6G+Ly6C+CD11bhigh MDSC, Ly6G+Ly6C+CD11blow PMN and Ly6G-Ly6C+ monocyte populations. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
10 Samples
Download data: CSV, TXT
Series
Accession:
GSE118796
ID:
200118796
10.

Cardiac fibroblasts regulate macrophage ontogeny, phenotype and function during cardiac injury

(Submitter supplied) Two types of monocytes, inflammatory and patrolling, infiltrate the hearts in both human myocarditis and murine experimental autoimmune myocarditis (EAM) model. The fates and functions of these infiltrating monocytes governing the progression of heart failure remain unclear. Here, we created parabiotic EAM and naïve mice to show that cardiac inflammation facilitate monocyte-to-macrophage differentiation. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL23038
9 Samples
Download data: CEL
Series
Accession:
GSE118861
ID:
200118861
11.

Ly6Chi monocytes in the inflamed colon give rise to pro-inflammatory effector cells and migratory antigen presenting cells.

(Submitter supplied) We showed different function of monocyte derived cells in the lamina propria of the colon under steady state and inflammatory conditions. We used microarrays to detail the global programme of gene expression and identified distinct clusters of regulated genes during this process.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
8 Samples
Download data: CEL
Series
Accession:
GSE42101
ID:
200042101
12.

Targeted deletion of an Nr4a1­ associated enhancer ablates Ly6Clow monocytes while protecting pleiotropic gene function in macrophages

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
24 Samples
Download data: BIGWIG
Series
Accession:
GSE80040
ID:
200080040
13.

Targeted deletion of an Nr4a1­ associated enhancer ablates Ly6Clow monocytes while protecting pleiotropic gene function in macrophages [RNA-seq]

(Submitter supplied) Mononuclear phagocytes are a diverse cell family that occupy all tissues and assume numerous functions to support tissue and systemic homeostasis. Our ability to investigate the roles of individual subsets is limited by an absence of approaches to ablate gene function within specific sub-populations. Using Nr4a1-dependent Ly6Clow monocytes as a representative cell type we show that enhancer deletion addresses these limitations. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
11 Samples
Download data: TXT
Series
Accession:
GSE80036
ID:
200080036
14.

Targeted deletion of an Nr4a1­ associated enhancer ablates Ly6Clow monocytes while protecting pleiotropic gene function in macrophages [ChIP-seq]

(Submitter supplied) Mononuclear phagocytes are a diverse cell family that occupy all tissues and assume numerous functions to support tissue and systemic homeostasis. Our ability to investigate the roles of individual subsets is limited by an absence of approaches to ablate gene function within specific sub-populations. Using Nr4a1-dependent Ly6Clow monocytes as a representative cell type we show that enhancer deletion addresses these limitations. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
13 Samples
Download data: BIGWIG
Series
Accession:
GSE80031
ID:
200080031
15.

Analysis of gene expression changes in mature colonic macrophages due to TGFβR1 deficiency

(Submitter supplied) We have analysed transcriptomic changes of colonic macrophages due to TGFβR1 deficiency.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL19795
6 Samples
Download data: TXT
Series
Accession:
GSE84765
ID:
200084765
16.

Transcriptomic analysis of monocyte to macrophage differentiation in the colon

(Submitter supplied) Intestinal macrophages rely on the constant replenishment by bone marrow derived Ly6Chigh monocytes in the adult organism. The developmental path from monocytes towards intestinal macrophages locally in the tissue is defined by the loss of Ly6C and acquisition of MHCII and CX3CR1 expression. We used microarray analysis to further characterise this local differentiation process.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
12 Samples
Download data: CEL
Series
Accession:
GSE84764
ID:
200084764
17.

Amyotrophic lateral sclerosis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL15846 GPL15847
48 Samples
Download data: TXT
Series
Accession:
GSE39644
ID:
200039644
18.

NanoString miRNA profiling of peripheral blood sorted CD14+CD16- monocytes from amyotrophic lateral sclerosis, multiple sclerosis and healthy control subjects

(Submitter supplied) We investigated the innate immune system in the SOD1 ALS model. We found that splenic Ly6CHi monocytes were activated and their progressive recruitment to the spinal cord, but not brain, correlated with neuronal loss. We found a decrease in resident microglia in the spinal cord with disease progression. Two months prior to disease onset, splenic Ly6CHi monocytes had an M1 signature which included increased CCR2. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL15847
24 Samples
Download data: TXT
Series
Accession:
GSE39643
ID:
200039643
19.

NanoString nCounter immune-related gene expression in blood sorted CD14+CD16- monocytes from sALS, fALS and HC subjects

(Submitter supplied) We investigated the innate immune system in the SOD1 ALS model. We found that splenic Ly6CHi monocytes were activated and their progressive recruitment to the spinal cord, but not brain, correlated with neuronal loss. We found a decrease in resident microglia in the spinal cord with disease progression. Two months prior to disease onset, splenic Ly6CHi monocytes had an M1 signature which included increased CCR2. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL15846
24 Samples
Download data: TXT
Series
Accession:
GSE39642
ID:
200039642
20.

Comparison of R1, R2 and R3

(Submitter supplied) 3 samples of R1, R2 and R3 bone marrow monocytes were compared from 3 biological replicates in 3 separate experiments. R1, R2 and R3 were sorted from triplicate experiments from pools of mice
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
9 Samples
Download data: CEL
Series
Accession:
GSE90471
ID:
200090471
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