GEO DataSets

(Submitter supplied) Plasmacytoid dendritic cells (pDCs) are a rare type of dendritic cells that exist antiviral functions in response to toll-like receptors (TLRs). We here report TLR4 activated pDCs similar to TLR7/8 stimulation. Despite the high resemblance, we found the unique genes that were activated by TLR4 activation.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28038

45 Samples

Download data: TXT

(Submitter supplied) In this study, we broadly investigated the nature and timing of SARS-CoV-2-induced changes in pDC gene expression, therefore we profiled 789 selected genes using NanoString nCounter technology after 4, 24 and 48 hrs in two individual donors found to be high (Dhigh) and low (Dlow) responders in terms of IFN production

Organism:

Homo sapiens

Type:

Other

Platform:

GPL31870

6 Samples

Download data: RCC, XLSX

(Submitter supplied) The purpose is to determine the role of TLR3-/- on the regulation of the host immune response during lethal SARS-CoV infection

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

52 Samples

Download data: TXT

(Submitter supplied) Purpose of experiment was to perform transcriptomic analysis on C57Bl/6 mice infected with different doses of SARS CoV MA15 at 4 different days post infection.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4134

92 Samples

Download data: TXT

(Submitter supplied) Toll like receptors (TLRs) sense microbial products and initiate adaptive immune responses by activating dendritic cells (DCs). Since pathogens may contain several agonists we asked whether different TLRs may synergize in DC activation. We report that in human and mouse DC TLR3 or TLR4 potently synergize with TLR7, TLR8 or TLR9 in the induction of selected cytokine genes. Upon synergistic stimulation, IL-12, IL-23 and Delta-4 are induced at levels 50-100 fold higher than those induced by optimal concentrations of single agonists, leading to enhanced and sustained TH1 polarizing capacity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1249

Platform:

GPL570

21 Samples

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Temporal analysis of monocyte-derived dendritic cells (DCs) treated with lipopolysaccharide (LPS), an agonist for toll-like receptor (TLR) 4, the synthetic imidazoquinoline resiquimod R848, an agonist for TLR8, or both. Provides insight into the synergistic effect of TLR agonists in activating DCs.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 4 agent, 3 time sets

Platform:

GPL570

Series:

GSE2706

21 Samples

Download data