Similar studies for GEO DataSets (Select 2104) - GEO DataSets

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Items: 2

Select item 21041.

Prostaglandin J2 effect on neuroblastoma cell line: time course

Analysis of neuroblastoma SK-N-SH cells at various time points up to 24 hours following treatment with prostaglandin J2 (PGJ2), a neurotoxic product of inflammation. Results provide insight into mechanisms of PGJ2-induced accumulation/aggregation of ubiquitinated proteins and to neuronal cell death.

Organism:: Homo sapiens

Type:: Expression profiling by array, log2 ratio, 4 time sets

Platform:: GPL3504
Series:: GSE4329
8 Samples

Download data: TXT

DataSet

Accession:: GDS2104

ID:: 2104

Select item 2000043292.

Prostaglandin J2 alters gene expression patterns and 26S proteasome assembly in human neuroblastoma cells

(Submitter supplied) Many neurodegenerative disorders are characterized by two pathological hallmarks: progressive loss of neurons and occurrence of inclusion bodies containing ubiquitinated proteins. The mechanisms responsible for these pathological features remain elusive. Inflammation may be critical to neurodegeneration associated with ubiquitin-protein aggregates. We previously showed that prostaglandin J2 (PGJ2), one of the endogenous products of inflammation, induces neuronal death and accumulation of ubiquitinated proteins into distinct aggregates. more...