GEO DataSets

Analysis of Paneth cells harvested by LCM from germ-free animals and previously germ-free animals reconstituted with normal intestinal flora. Paneth cells are key effectors of small intestinal antimicrobial defense. Results provide insight into how intestinal surfaces cope with microbial challenges.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL1261

Series:

GSE5156

4 Samples

Download data: CEL, EXP

(Submitter supplied) This study delineated how small intestinal resident microflora impact gene expression in Paneth cells. Keywords: functional genomics; transcriptional profiling

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2163

Platform:

GPL1261

4 Samples

Download data: CEL, EXP

(Submitter supplied) Paneth cells of intestinal crypts contribute to host defense by producing antimicrobial peptides that are packaged as granules for secretion into the crypt lumen. Here, we provide evidence using light and electron microscopy that postsecretory Paneth cell granules undergo limited dissolution and accumulate within the intestinal crypts of cystic fibrosis (CF) mice. On the basis of this finding, we evaluated bacterial colonization and expression of two major constituents of Paneth cells, i.e., {alpha}-defensins (cryptdins) and lysozyme, in CF murine intestine. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL444

1 Sample

Download data

(Submitter supplied) The Incyte Unigem1.31 contains 9,500 mouse clones. The PCR amplified DNA inserts were purified and mechanically spotted onto the array chip by Incyte Genomics.

Organism:

Mus musculus

1 Series

1 Sample

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(Submitter supplied) Intestinal epithelial cells of 28-day-old female mice were isolated according to a recently published protocol (Lotz et al., J Exp. Med. 2006).

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4134

20 Samples

Download data: TXT