GEO DataSets

Analysis of left heart ventricles (LV) at various time points up to 48 hours following surgically induced acute myocardial infarction (AMI). Ischemic/infarcted tissue, surviving free wall, and the interventricular septum of LV examined. Results provide insight into the molecular pathogenesis of AMI.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 disease state, 7 time, 4 tissue sets

Platform:

GPL83

Series:

GSE4648

66 Samples

Download data: CEL

(Submitter supplied) We report a genome-wide survey of early responses of the mouse heart transcriptome to acute myocardial infarction (AMI). For three regions of the left ventricle (LV), namely ischemic/infarcted tissue (IF), the surviving LV free wall (FW) and the interventricular septum (IVS), 36,899 transcripts were assayed at six time points from 15 min to 48 h post-AMI in both AMI and sham surgery mice. For each transcript, temporal expression patterns were systematically compared between AMI and sham groups, which identified 515 AMI-responsive genes in IF tissue, 35 in the FW, 7 in the IVS, with three genes induced in all three regions. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS2329 GDS2330 GDS2331

Platforms:

GPL83 GPL81 GPL82

198 Samples

Download data: CEL

Analysis of left heart ventricles (LV) at various time points up to 48 hours following surgically induced acute myocardial infarction (AMI). Ischemic/infarcted tissue, surviving free wall, and the interventricular septum of LV examined. Results provide insight into the molecular pathogenesis of AMI.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 disease state, 7 time, 4 tissue sets

Platform:

GPL82

Series:

GSE4648

66 Samples

Download data: CEL

Analysis of left heart ventricles (LV) at various time points up to 48 hours following surgically induced acute myocardial infarction (AMI). Ischemic/infarcted tissue, surviving free wall, and the interventricular septum of LV examined. Results provide insight into the molecular pathogenesis of AMI.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 disease state, 7 time, 4 tissue sets

Platform:

GPL81

Series:

GSE4648

66 Samples

Download data: CEL

(Submitter supplied) Myocardial infarction (MI), the most severe manifestation of coronary artery disease, is a multifactorial pathophysiologic process. Here, we constructed a MI mouse model through ligation of the proximal left anterior descending coronary artery. Then we detected and analysed multi-omics (transcriptome and proteome) at different time points (Control, 10 mininte, 1 hour, 6 hour, 24 hour and 72 hour) after MI. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

18 Samples

Download data: CSV