GEO DataSets

Analysis of dendritic cell (DC) development from Flt3(+)CD11b(+) DC progenitors. DC progenitors treated with GM-CSF for 7 and 10 days to induce differentiation. DCs differentiated for 10 days were subsequently treated with TNFalpha to induce maturation.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 protocol sets

Platform:

GPL32

Series:

GSE575

4 Samples

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(Submitter supplied) Assessing the gene expression repertoire of antigen presenting dendritic cells Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

7 Samples

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(Submitter supplied) sorted hematopoetic stem cells from bone marrow; with two rounds of amplification Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

2 Samples

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(Submitter supplied) FLT3+/CD11b+ Dendritic cell (DC) progenitor was amplified in vitro from mouse bone marrow. Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

5 Samples

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(Submitter supplied) FLT3+CD11b+ DC progenitor was amplified in vitro from mouse bone marrow. DC were differentiated using GM-CSF and analyzed at day 7 and day 10 of differentiation and after 16h TNFalpha stimulation at day 10 Keywords: time-course

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2440

Platform:

GPL32

4 Samples

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(Submitter supplied) Dendritic cells (DCs) in lymphoid tissue comprise conventional DCs (cDCs) and plasmacytoid DCs (pDCs) that develop from common DC progenitors (CDPs). CDPs are Flt3+c-kitintM-CSFR+ and reside in bone marrow. Here we describe a two-step culture system that recapitulates DC development from c-kithiFlt3-/lo multipotent progenitors (MPPs) into CDPs and further into cDC and pDC subsets. MPPs and CDPs are amplified in vitro with Flt3 ligand, stem cell factor, hyper-IL-6 and insulin- like growth factor-1. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

20 Samples

Download data: CEL

(Submitter supplied) We hypothesize that under homeostatic as well as inflammatory conditions circulating monocytes and/or their bone marrow-derived progenitors might contribute to the replenishment of CD103+ and CD103- DC in lymphoid and non-lymphoid compartments. To that end, bone marrow cells from CX3CR1+/gfp C57BL/6 mice were sorted as follows: lineage negative (CD3, CD19, NK1.1, Ter119, Ly6G and CD11c) CX3CR1+c-kit+. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4134

2 Samples

Download data: TXT

(Submitter supplied) Pulmonary dendritic cells are heterogenous cells comprise four distinct subsets including two conventional dendritic cell subsets, CD103+ and CD11bhiCD14lo cells, and two monocyte-derived dendritic cell subsets. Their functions in terms of migration and T cell activation are distinct, but genes regulating their features are to be determined. We used microarrays to identify a select set of genes that are expressed in conventinal dendritic cells and in monocyte-derived dendriti cells.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5663

Platform:

GPL1261

12 Samples

Download data: CEL, CHP

Analysis of four dendritic cell (DC) subsets purified from the lungs of C57BL/6 males following inhalation of LPS/OVA. The four subsets represent conventional DCs (cDCs) and monocyte-derived DCs (moDCs). Results provide insight into molecular profiles that would discriminate between cDCs and moDCs.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 cell type, 2 other sets

Platform:

GPL1261

Series:

GSE64896

12 Samples

Download data: CEL, CHP

(Submitter supplied) Bcl11a is a transcription factor known to regulate lymphoid and erythroid development. Recent bioinformatic analysis of global gene expression patterns has suggested a role for Bcl11a in the development of dendritic cell (DC) lineages. We tested this hypothesis by analyzing the development of DC and other lineages in Bcl11a(-/-) mice. We show that Bcl11a is required for expression of IL-7 receptor (IL-7R) and Flt3 in early hematopoietic progenitor cells. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

4 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

16 Samples

Download data: CEL

(Submitter supplied) The goal of this study was to determine whether there are any gene expression changes in pDCs from WT and Flt3 KO mice. Specifically whether developing in the absence of Flt3 signaling had any effects on the gene expression of the pDCs

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

4 Samples

Download data: CEL

(Submitter supplied) The goal of this study was to determine whether there are any gene expression changes in cDC1s and cDC2s from WT, Flt3 KO, or Flt3L KO mice. Specifically whether developing in the absence of Flt3 signaling had any effects on the gene expression of the cDCs

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

12 Samples

Download data: CEL

(Submitter supplied) Runx/Cbfb heterodimers play important roles in the development of hematopoietic cells in mouse embryos and adults. In order to identify genes that are regulated by Runx/Cbfb, we purified Lin– c-kit+ Sca1+ (LSK) cells and Lin– c-kit+ Sca1– CD16/32+ (GMP) cells from Vav1-iCre x Cbfb(F/F) and Vav1-iCre x Cbfb(F/+) mice and profiled gene expression using microarray.

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS5413 GDS5414

Platform:

GPL6246

8 Samples

Download data: CEL

Analysis of purified Lin-c-kit+Sca1-CD16/32+ GMP cells from Cbfβ-conditional knockout mice. Runx/Cbfb heterodimers play important roles in hematopoietic cell development. Results provide insight into molecular mechanisms by which Cbfβ regulates cell fate decisions in bone marrow progenitors.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL6246

Series:

GSE55227

4 Samples

Download data: CEL

Analysis of purified Lin-c-kit+Sca1+ LSK cells from Cbfβ- conditional knockout mice. Runx/Cbfb heterodimers play important roles in hematopoietic cell development. Results provide insight into molecular mechanisms by which Cbfβ regulates cell fate decisions in bone marrow progenitors.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL6246

Series:

GSE55227

4 Samples

Download data: CEL

(Submitter supplied) Functional genomics comparison of EBFko, Pax5ko, and RAG2ko cell lines. Identify gene signatures associated with specfication and commitment to the B cell fate.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

9 Samples

Download data: CEL, CHP, XLS

(Submitter supplied) To understand the functional relationship between brain dendritic cells (brain DCs) and other myeloid cells, we compared the gene expression profile of m/chDCs to that of bone marrow monocytes, brain microglia and classical spleen CD8+ and CD8- DCs. In order to obtain enough brain DCs for mRNA extraction, we expanded brain DCs with in vivo Flt3L treatment before purification.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

14 Samples

Download data: CEL

(Submitter supplied) Comparison of gene expression changes of FACS sorted splenic CD11b+CD8a- and CD11b-CD8a+ cDC subsets reconstituted in vivo following total body irradiation in combination with exogenous retinoic acid or vehicle control.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

16 Samples

Download data: CEL

(Submitter supplied) Dendritic cells (DCs) in tissues and lymphoid organs comprise distinct functional subsets that differentiate in situ from circulating progenitors. Tissue-specific signals that regulate DC subset differentiation are poorly understood. We report that DC-specific deletion of the Notch2 receptor caused a reduction of DC populations in the spleen. Within the splenic CD11b+ DCs, Notch signaling blockade ablated a distinct population marked by high expression of adhesion molecule Esam. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

3 Samples

Download data: CEL, CHP