GEO DataSets

Analysis of peripheral blood lymphocytes (PBL) subjected to hypoxia in vitro. PBL were grown at 1% or 20% ambient oxygen.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 stress sets

Platform:

GPL2507

Series:

GSE7833

6 Samples

Download data

(Submitter supplied) The aim of the study is to evaluate oxygen regulated gene expression in human peripheral blood lymphocytes using microarray analysis. The results of this study are expected to provide useful marker transcripts whose expression is highly affected by hypoxia for further hypoxic gene expression studies using peripheral blood lymphocytes. Keywords: peripheral blood lymphocytes, hypoxia-regulated transcripts

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2951

Platform:

GPL2507

6 Samples

Download data: TXT

(Submitter supplied) Reduced or absent cytotrophoblast invasion of the maternal uterine spiral arteries is a common clinical finding in studies of pregnancies complicated by preeclampsia, suggesting that the mechanisms behind invasion of these cells is perturbed. The placenta initially develops in a low oxygen environment of 1-2% oxygen until after the 10th week of pregnancy. During this time oxygen concentration exerts a major influence over trophoblast activity and, in vitro, hypoxia inducible factors are proposed to be one of many key regulators of first trimester trophoblast behaviour. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

18 Samples

Download data: IDAT

(Submitter supplied) The goal of the study was to identify hypoxia-induced gene expression changes in C. elegans and to determine which of these responses to hypoxia were regulated by hif-1. Towards these aims, we analyzed mRNA expression patterns in synchronized populations of wild-type worms that were cultured in standard lab conditions (normoxia) or in hypoxia. We also assayed mRNA from two mutant strains: (i) animals carrying the strong loss-of-function mutation in hif-1 and (ii) C. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Dataset:

GDS1379

Platform:

GPL2569

9 Samples

Download data

Analysis of wild type, hif-1-deficient, and vhl-1-deficient strains cultured for 4 hours in 21% oxygen (normoxia) or 0.1% oxygen (hypoxia). Results provide insight into pathways for adaptation to oxygen deprivation.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, log2 ratio, 3 strain sets

Platform:

GPL2569

Series:

GSE2836

9 Samples

Download data

(Submitter supplied) In order to study the gene expression profile in C57Bl/10 mouse blood, we exposed three different groups of animals. First was exposed to PO2 21% or normoxia. The second was exposed to chronic hypoxia (from PO2 21% to PO2 8%) and the third was also exposed to the same chronic hypoxia (CH) protocol but followed by two weeks under normoxia, and called as recovery group. The blood was extracted from inferior vena cava, the RNA was extracted, amplified and hybridized to Affimetrix MOE 430 V2.o chip. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

12 Samples

Download data: CEL, CHP