Similar studies for GEO DataSets (Select 3086) - GEO DataSets

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Items: 2

Select item 30861.

Iron overload effect on cardiac and skeletal muscles

Analysis of cardiac and skeletal muscles of animals fed a high-iron diet to induce iron overload. The cardiac muscle is a tissue affected by iron overload. Result provides insight into the molecular mechanisms underlying the pathological effect of iron overload on muscle cells.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 protocol, 2 tissue sets

Platform:: GPL4234
Series:: GSE9726
12 Samples

Download data: TXT

DataSet

Accession:: GDS3086

ID:: 3086

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000097262.

Effects of iron overload on gene expression in the cardiac and skeletal muscle of mice

(Submitter supplied) Hereditary Hemochromatosis (HH) is an autosomal recessive disorder characterized by an abnormally low expression or functional derangement of the iron regulatory hormone hepcidin. The absorption of dietary iron is disproportionate in these patients, leading to iron deposition in several tissues and consequent damage of organs including liver, heart, and pancreas. Late complications in absence of diagnosis and treatment include cirrhosis, hepatocellular carcinoma, cardiomyopathy and diabetes. more...