GEO DataSets

Analysis of ectopic endometrial tissues implanted in the peritoneal cavity of 11 subjects. The growth of endometrial tissue outside of the uterus is called endometriosis. Results provide insight into the molecular pathology of endometriosis.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state, 11 individual sets

Platform:

GPL2895

Series:

GSE5108

22 Samples

Download data

(Submitter supplied) Brief description of the experiment: The objective of this experiment was to use DNA microarrays to identify differentially expressed genes in eutopic uterine endometrium compared to ectopic endometrium. 174 of the 53,000 genes on the whole human DNA microarrays were changed by 5-fold or greater in ectopic vs. eutopic endometrium. Families of genes that were differentially expressed include immune system and inflammatory pathway genes, genes whose cognate proteins code for cell adhesion, junctional proteins, the extracellular matrix and its remodeling, and cytoskeletal proteins, and ligands, receptors, and components of specific signal transduction pathways. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3092

Platform:

GPL2895

22 Samples

Download data

(Submitter supplied) The pathogenesis of endometriosis may result from aberrant angiogenesis that occurs in eutopic endometrium with retrograde menstruation. The difference in gene expression profile between human endometrial endothelial cells (HEECs) from eutopic endometria of patients with and without endometriosis would be determinant that affects the occurrence of endometriosis. To explore this kind of difference, we performed in vitro culture and identified their endothelial origin, as well as observed growth features of HEECs from the two different origins. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3060

Platform:

GPL570

10 Samples

Download data: CEL

Analysis of cultured endometrial endothelial cells derived from the eutopic endometria of patients with endometriosis. Results provide insight into the role of aberrant angiogenesis in the pathogenesis of endometriosis.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL570

Series:

GSE7846

10 Samples

Download data: CEL

(Submitter supplied) Endometriosis is a common gynecological disorder characterized by pain and infertility, where the lesions disseminate everywhere in the body with a preference for the pelvis. In that, it could be regarded as a “benign metastatic disease”, since its issue is not fatal. However, the molecular bases of this intriguing clinical condition are not well known. The objective of this study is to characterize the transcriptome differences between eutopic vs ectopic endometrium with a special interest in pathways involved in cancerogenesis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL7304

4 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Methylation profiling by array

Platforms:

GPL13534 GPL17425

12 Samples

Download data: PAIR

(Submitter supplied) Endometriosis is a common gynecological disease that affects 10-20% of women in child-bearing age. It is defined by the presence of endometrial tissues outside the uterus. The causes remain elusive, but the endometrium of these patients differs profoundly from that of disease-free subjects. During pregnancy, the maternal-fetal interface is built onto decidualized endometrium. We investigated whether this interface is normal when the subjects suffer of endometriosis and showed remarkly properties of eutopic endometrium from endometriosis-affected women to spontaneously develop endometriotic-like lesions within direct contact to non-uterine tissues.

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL13534

6 Samples

Download data: TXT

(Submitter supplied) Endometriosis is a common gyncological disease that affects 10-20% of women in child-bearing age. It is defined by the presence of endometrial tissues outside the uterus. The causes remain elusive, but the endometrium of these patients differs profoundly from that of disease-free subjects. During pregnancy, the maternal-fetal interface is built onto decidualized endometrium. We investigated whether this interface is normal when the subjects suffer of endometriosis and showed remarkly properties of eutopic endometrium from endometriosis-affected women to spontaneously develop endometriotic-like lesions within direct contact to non-uterine tissues.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17425

6 Samples

Download data: PAIR, TXT

(Submitter supplied) Decidualization is a critical process for embryo implatation during which uterine stromal fibroblasts are transformed into large, epithelioid-like decidual cell. NOTCH1 is recepotor of Notch signaling that plays important roles for cell-cell communication, which involves gene regulatory mechanisms that control multiple cellular differentiation processes during embryonic and adult life. Here we silenced NOTCH1 by shRNA in HuF cells and studied how it affects decidualization

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

8 Samples

Download data: CEL

(Submitter supplied) Endometriosis is a complex pathological condition in which multiple components are involved in the disease development and clinical outcome. Endometriosis is mainly an inflammatory codition estrogen-dependent, with unknown pathogenesis, that is characterized by dissemination of edometrium tissue in ectopic position (ovary or pelvic peritoneum). Two main theories rise the pathologic onset: the presence of retrograde menstruation and celomic metaplasia in the pelvic peritoneum, that can occur for development defects. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5339

Platform:

GPL571

22 Samples

Download data: CEL

Analysis of ectopic endometria and eutopic endometria from endometriosis patients. Endometriosis is characterized by the presence of endometrial tissue at extra-uterine sites. Results provide insight into the molecular mechanisms underlying endometriosis pathogenesis.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state, 3 tissue sets

Platform:

GPL571

Series:

GSE25628

22 Samples

Download data: CEL

(Submitter supplied) In this study, we performed transcriptomic analysis in ectopic lesions and eutopic endometrial tissues from both fertile and subfertile mice with endometriosis. We identified the positive correlation of the gene signatures between the mouse and human in ectopic lesions. Conserved gene networks were activated in all the ectopic lesions including estradiol, immune, fibrosis, and angiogenesis pathways. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

24 Samples

Download data: TXT

(Submitter supplied) Comparison of macrophages M1 (M1) and M2 (M2) from eutopic endometrium from women with and without endometriosis

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20301

18 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array

Platforms:

GPL81 GPL8300 GPL96

36 Samples

Download data: CEL

(Submitter supplied) The pathophysiology of endometriotic lesion development remains unclear but involves a complex interaction between ectopic endometrium and host peritoneal tissues. We hypothesised that disruption of this interaction was likely to suppress endometriotic lesion formation. We hoped to delineate the molecular and cellular dialogue between ectopic human endometrium and peritoneal tissues in nude mice, as a first step towards testing this hypothesis. more...

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array

Platforms:

GPL8300 GPL81

18 Samples

Download data: CEL

(Submitter supplied) The pathophysiology of endometriotic lesion development remains unclear but involves a complex interaction between ectopic endometrium and host peritoneal tissues. We hypothesised that disruption of this interaction was likely to suppress endometriotic lesion formation. We hoped to delineate the molecular and cellular dialogue between ectopic human endometrium and peritoneal tissues in nude mice, as a first step towards testing this hypothesis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

18 Samples

Download data: CEL

(Submitter supplied) Endometriosis is defined as the presence of endometrial tissue (eutopic tissue) outside the uterus (ectopic tissue). We assessed differentially expressed microRNAs in ectopic endometrium compared with eutopic endometrium.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL7372

3 Samples

Download data: TXT

(Submitter supplied) Eutopic endometrium in endometriosis has molecular evidence of resistance to progesterone (P4) and activation of the PKA pathway in the stromal compartment. To investigate global and temporal responses of eutopic endometrium to P4, we compared early (6-h), intermediate (48-h), and late (14-day) transcriptomes, signaling pathways, and networks of human endometrial stromal fibroblasts (hESFs) from women with endometriosis (hESFendo) to hESFs from women without endometriosis (hESFnonendo). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

80 Samples

Download data: CEL, TXT

(Submitter supplied) Several lines of evidence indicate that endometriosis could be partially due to epigenetic dysregulations. Hypermethylation of some key gene promoters, such as progesterone receptor or aromatase, has been reported to be associated with silencing of these genes. However, it is unknown whether global alterations in DNA methylation are a hallmark of endometriosis and to what extent they are involved in its pathogenesis. more...

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL5082

4 Samples

Download data: BAR, CEL, TXT