GEO DataSets

Analysis of circulating B lymphocytes from postmenopausal women with low or high bone mineral density (BMD). Osteoporosis is characterized by low BMD. Results provide insight into the role of B cells in bone metabolism and osteoporosis.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state sets

Platform:

GPL96

Series:

GSE7429

20 Samples

Download data: CEL, EXP

(Submitter supplied) B cells produce important cytokines regulate bone metabolism. We comparison gene expression patterns of circulating B cells in blood from 20 postmenopausal females with low or high bone mineral density (BMD): 10 low BMD vs. 10 high BMD. In total 29 differentially expressed genes were identified including some novel genes to be relevant to bone metabolism. These results provide insight into the role of B cells in pathologic osteoporosis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3353

Platform:

GPL96

20 Samples

Download data: CEL, EXP

(Submitter supplied) Monocytes were isolated from 30 ml of whole blood from each of 19 women, 10 with high BMD and 9 with low BMD, using monocyte negative isolation kit from Dynal Biotech Inc. Total RNA was extracted from monocytes using Qiagen RNeasy Mini Kit. Targets were produced for each subject using standard Affymetrix procedures from about 4ug of total RNA. Hybridization was made for each subject. Comparison was performed between 10 high BMD and 9 low BMD subjects. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1287

Platform:

GPL96

19 Samples

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Comparison of circulating monocytes from pre- and postmenopausal females with low or high bone mineral density (BMD). Circulating monocytes are progenitors of osteoclasts, and produce factors important to bone metabolism. Results provide insight into the role of monocytes in osteoporosis.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 development stage, 2 disease state sets

Platform:

GPL96

Series:

GSE2208

19 Samples

Download data

(Submitter supplied) B cells were found to be directly associated with the onset and development of many smoking-induced diseases. However, the in vivo molecular response of B cells underlying the female cigarette smoking remains unknown. Using the genome-wide Affymetrix HG-133A GeneChip® microarray, we compared the gene expression profiles of peripheral circulating B cells between 39 smoking and 40 non-smoking healthy US white females.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3713

Platform:

GPL96

79 Samples

Download data: CEL

Analysis of peripheral circulating B cells from smoking and non-smoking healthy US white females. B cells are directly associated with the onset and development of many smoking-induced diseases. Results provide insight into the molecular basis of B cell involvement in smoking-related pathogenesis.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 stress sets

Platform:

GPL96

Series:

GSE18723

79 Samples

Download data: CEL