Similar studies for GEO DataSets (Select 3471) - GEO DataSets

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Items: 2

Select item 34711.

B-precursor acute lymphoblastic leukemia tumors sensitive and resistant to ionizing radiation

Analysis of B-precursor acute lymphoblastic (ALL) tumor cells exposed to ionizing radiation (IR) to induce DNA damage in vitro. Half of the tumors are sensitive to IR induced apoptosis. Results provide insight into the molecular basis of the differences in response of B-precursor ALL to IR.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 agent, 2 disease state, 22 individual sets

Platform:: GPL96
Series:: GSE13280
44 Samples

Download data: CEL

DataSet

Accession:: GDS3471

ID:: 3471

Select item 2000132802.

Gene expression analysis of paediatric acute lymphoblastic leukaemia

(Submitter supplied) We addressed the clinical significance and mechanisms behind in vitro cellular responses to ionising radiation (IR)-induced DNA double strand breaks in 74 paediatric ALL patients. We found an apoptosis-resistant response in 36% of patients and an apoptosis-sensitive response in the remaining 64% of leukaemias. Global gene expression profiling of 11 apoptosis-resistant and 11 apoptosis-sensitive ALLs revealed abnormal up-regulation of multiple pro-survival pathways in response to IR in apoptosis-resistant leukaemias and differential post-transcriptional activation of the PI3-Akt pathway was observed in representative resistant cases. more...