GEO DataSets

Analysis of healthy intestinal mucosa biopsies from 10 monozygotic and 10 dizygotic twin pairs. Barrier organs such as the gut are exposed to continual environmental challenge. Results provide insight into genetic and non-genetic determinants of gene expression.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 gender, 2 genotype/variation, 20 other sets

Platform:

GPL570

Series:

GSE7821

40 Samples

Download data: CEL, CHP

(Submitter supplied) Background and aims. The etiopathology of inflammatory bowel diseases is still poorly understood. To date, only few little data are available on the microbiota composition in ulcerative colitis (UC), representing a major subform of inflammatory bowel diseases. Currently, one of the main challenges is to unravel the interactions between genetics and environmental factors in the onset or during the progression and maintenance of the disease. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4519

Platform:

GPL570

20 Samples

Download data: CEL

(Submitter supplied) Whole genome expression profiling of 40 healthy human twins (20 monozygotic, 20 dizygotic) Keywords: heritability test

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3630

Platform:

GPL570

40 Samples

Download data: CEL, CHP

Analysis of colon mucosal tissue from 10 monozygotic (MZ) twins discordant for ulcerative colitis (UC). Twins (paired samples) were analyzed to obtain mucosal response data independent of genetic variation. Results provide insight into molecular mechanisms underlying UC.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state, 10 individual sets

Platform:

GPL570

Series:

GSE22619

20 Samples

Download data: CEL

(Submitter supplied) Pouchitis is a common complication for ulcerative colitis (UC) patients with ileal pouch-anal anastomosis (IPAA) surgery. Similarly to IBD, both innate host factors such as genetics, and environmental stimuli including the tissue-associated microbiome have been implicated in the pathogenesis. In this study, we make use of the IPAA model of inflammatory bowel disease (IBD) to carry out a study associating mucosal host gene expression with the microbiome and corresponding clinical outcomes.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

273 Samples

Download data: CEL

(Submitter supplied) Acute lymphoblastic leukemia (ALL) is an heterogeneous disease comprising several subentities that differ for both immunophenotypic and molecular characteristics. Over the years, the biologic understanding of this neoplasm has largely increased. Gene expression profiling has recently allowed to identify specific signatures for the different ALL subsets and permitted identification of pathways deregulated by a given lesion. more...

Organism:

Homo sapiens

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL570 GPL8191

39 Samples

Download data: CEL, XLS

(Submitter supplied) We investigated transcriptional response of CaCo-2 cells to iron treatments, we studied hemin effect by adding hemin to DMEM-FBS medium and iron deficiency effects in using an iron free medium compared to the same supplemented with FAC (ferric ammonium citrate). Keywords: various iron treatment, differential gene expression, hemin treatment, iron-free

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2230

Platform:

GPL887

12 Samples

Download data

Analysis of intestinal CaCo-2 cell line grown in medium free of iron or supplemented with hemin to mimic iron overload. Intestinal iron absorption is crucial for systemic iron homeostasis. Results provide insight into molecular mechanisms regulating iron metabolism.

Organism:

Homo sapiens

Type:

Expression profiling by array, log10 ratio, 4 agent, 2 growth protocol sets

Platform:

GPL887

Series:

GSE3573

12 Samples

Download data

(Submitter supplied) Paternal exposure to genotoxic compounds is thought to contribute to diseases in their offspring. Therefore, mRNA profiles from sperm in ejaculates of cigarette smokers (N=4) were compared with non-smokers (N=4). Smoking behaviour was verified by assessing cotinine levels in seminal plasma. Gene-expression analysis was subsequently performed using microarray technology (Agilent human 4x44k) to investigate the use of gene-expression profiling as biomarker of gene-environment interactions in human testis

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6480

8 Samples

Download data: TXT

(Submitter supplied) In order to investigate the patterns of genetic lesions in a panel of 23 Human Multiple Myeloma Cell Lines (HMCLs), we made a genomic integrative analysis involving FISH and both gene expression and genome-wide profiling approaches. The expression profiles of the genes targeted by the main IGH translocations showed that the WHSC1/MMSET gene involved in t(4;14)(p16;q32) was expressed at different levels in all of the HMCLs, and that the expression of the MAF gene was not restricted to the HMCLs carrying t(14;16)(q32;q23). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

23 Samples

Download data: CEL