GEO DataSets

Analysis of skeletal muscle (SM) from transgenics deficient in retinoic acid receptor-related orphan receptor (ROR) alpha 1delDE. SM accounts for significant levels of lipid catabolism; ROR alpha is involved in regulating lipid metabolism. Results provide insight into ROR alpha1 signaling in SM.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL6105

Series:

GSE20646

6 Samples

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(Submitter supplied) Identification and validation of the pathways and functions regulated by the orphan nuclear receptor, ROR alpha1, in skeletal muscle The retinoic acid receptor-related orphan receptor (ROR) alpha has been demonstrated to regulate lipid metabolism. We were interested in the physiologically relevant roles, and pathways regulated by RORalpha1 action in skeletal muscle. This major mass organ accounts for ~40% of the total body mass, and significant levels of lipid catabolism, glucose disposal and energy expenditure. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3720

Platform:

GPL6105

6 Samples

Download data: TXT

(Submitter supplied) Retinoid-related orphan receptors RORalpha and RORgamma are both expressed in liver; however, their physiological functions have not yet been clearly defined. RORalpha1 and RORgamma1, but not RORalpha4, show an oscillatory pattern of expression during circadian rhythm. To obtain insight into the physiological functions of ROR receptors in liver, we analyzed the gene expression profiles of livers from WT, RORalpha-deficient staggerer mice (RORalphasg/sg), RORgamma-/-, and RORalpha sg/sgRORgamma-/- double knockout (DKO) mice by microarray analysis. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL891

10 Samples

Download data: TIFF, TXT

(Submitter supplied) Expression profiles of mouse skeletal muscle tissues, mouse skeletal muscle from Aged animals with high fat diet and chemical treatment

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

6 Samples

Download data: XLSX