GEO DataSets

Temporal analysis of chondrocytes from osteoarthritic knee joints and mesenchymal stem cells from bone marrow of healthy donors, grown in a pellet culture system under chondrogenic conditions. Results provide insight into molecular mechanisms underlying chondrogenic commitment of both cell types.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 cell type, 4 time sets

Platform:

GPL9828

Series:

GSE19664

8 Samples

Download data: CEL

(Submitter supplied) The recruitment of mesenchymal stem cells in order to reconstruct damaged cartilage of osteoarthritis joints is a challenging tissue engineering task. Vision towards this goal is blurred by a lack of knowledge about the underlying differences between chondrocytes and MSC during the chondrogenic cultivation process. The aim of this study was to shed light on the differences between chondrocytes and MSC occurring during chondral differentiation through tissue engineering. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3785

Platform:

GPL9828

8 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Methylation profiling by array

Platforms:

GPL11532 GPL8490

64 Samples

Download data: CEL

(Submitter supplied) The aim of this study is to identify, for the first time, the genome-wide DNA methylation profiles of human articular chondrocytes from OA and healtly cartilage samples. Genome wide DNA methylation profiling of normal and osteoarthritic samples. The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs in cartilage knee samples. more...

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL8490

41 Samples

Download data: TXT

(Submitter supplied) The aim of this study is to identify, for the first time, the genome-wide DNA methylation profiles of human articular chondrocytes from OA and healtly cartilage samples. A subsequent validation of methylation profiles were performed in an idependent cohort of OA samples with Affymetrix Hugene 1.1 st array This represents the gene expression component of the study only

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

23 Samples

Download data: CEL

(Submitter supplied) We performed RNA sequencing on several clones of bovine mesenchymal stem cells from the same donor.

Organism:

Bos taurus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL15749

18 Samples

Download data: TSV, TXT

(Submitter supplied) Cartilage plays a fundamental role in the development of the human skeleton. Early in embryogenesis, mesenchymal cells condense and differentiate to chondrocytes to shape the early skeleton. Subsequently, the cartilage anlagen differentiate to form the growth plates, which are responsible for linear bone growth, and the articular chondrocytes, which facilitate joint function. However, despite the multiplicity of roles of cartilage during human fetal life, surprisingly little is known about its transcriptome. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL570 GPL96 GPL97

14 Samples

Download data: CEL

(Submitter supplied) Chronic inflammation leading to pro-inflammatory macrophage infiltration contributes to the pathogenesis of type 2 diabetes and subsequently the development of diabetic nephropathy. Mesenchymal stem cells (MSCs) possess unique immunomodulatory and cytoprotective properties making them an ideal candidate for therapeutic intervention We used microarrays to detail changes in the gene expression profile of monocytes isolated from type 2 diabetic patients with end-stage renal disease and non-diabetic control subjects following co-culture with MSCs.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL16686

18 Samples

Download data: CEL