GEO DataSets

Analysis of HUVECs cultured for 24 h at a normal laminar shear stress (LSS15) or elevated shear stress (LSS75). LSS is a key regulator of endothelial function that underlies protection or predilection for atherogenesis. Results provide insight into the effect of increased LSS on the endothelium.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 stress sets

Platform:

GPL6104

Series:

GSE23289

8 Samples

Download data

(Submitter supplied) Many studies have characterised the effect of normal laminar shear stress (LSS) on endothelial responses, however elevated shear stress, as would be experienced overlying a stenotic plaque, has not been studied in depth. Therefore we used transcriptomics and related functional analyses to compare cells exposed to laminar shear stress at 15 or 75 dynes/cm2 for 24 hours (LSS15-normal or LSS75-high shear stress).

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3868

Platform:

GPL6104

8 Samples

Download data: TXT

(Submitter supplied) Laminar shear stress due to constant blood flow is known to play a critical role in maintaining vascular health. In contrast, endothelial cell senescence appears to be closely associated with the incidence of vascular disorder. In an attempt to identify functional biomarkers for age-related vascular health/disease, the present study investigated differential gene expression of young and senescent human umbilical vein endothelial cells (HUVECs) under static and laminar shear stress. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

12 Samples

Download data: CEL