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Links from GEO DataSets

Items: 8

1.
Full record GDS3954

Polychlorobiphenyl non-coplanar congener PCB-153 effect on liver cell line

Analysis of a metabolically competent HepG2 cells exposed to PCB-153, a prototype non-coplanar congener of polychlorobiphenyls (PCB). Different congeners of PCB lead to varying degrees of cellular oxidative stress. Results provide insight into the mechanism of action of non-coplanar PCB congeners.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 5 time sets
Platform:
GPL570
Series:
GSE6878
16 Samples
Download data: CEL
2.

Expression data from human liver cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS3954 GDS3955
Platform:
GPL570
28 Samples
Download data: CEL
Series
Accession:
GSE6878
ID:
200006878
3.

Expression data from human liver cell line induced by PCB77

(Submitter supplied) Exposure to Polychlorobiphenyls (PCBs) is known to cause serious health effects in human but the gene expression profiles leading to development of different diseases is not fully understood. The knowledge of global gene expression will help us to develop early diagnostic biomarkers for PCB induced health effects. We used microarrays to detail the global gene expression profile underlying the effects of PCB77 on human liver cells leading to identification of distinct classes of up-regulated and down-regulated genes and cellular processes. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
12 Samples
Download data: CEL
Series
Accession:
GSE6869
ID:
200006869
4.

Expression data from human liver cell line induced by PCB153

(Submitter supplied) Exposure to Polychlorobiphenyls (PCBs) is known to cause serious health effects in human but the gene expression profiles leading to development of differnet diseases is not fully understood. The knowledge of global gene expression will help us to devlop early diagnostic biomarkers for PCB induced health effects. We used microarrays to detail the global gene expression profile underlying the effects of PCB153 on human liver cells leading to identification of distinct classes of up-regulated and down-regulated genes and cellular processes. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
16 Samples
Download data: CEL
Series
Accession:
GSE6494
ID:
200006494
5.
Full record GDS3955

Polychlorobiphenyl coplanar congener PCB-77 effect on liver cell line

Analysis of a metabolically competent liver cell line HepG2 exposed to coplanar PCB-77, a prototype congener of polychlorobiphenyls (PCB). Different congeners of PCB lead to varying degrees of cellular oxidative stress. Results provide insight into the mechanism of action of coplanar PCB congeners.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 4 time sets
Platform:
GPL570
Series:
GSE6878
12 Samples
Download data: CEL
6.

Divergent Transcriptomic Responses to Aryl Hydrocarbon Receptor Agonists Between Rat and Human Primary Hepatocytes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Rattus norvegicus
Type:
Expression profiling by array
Platforms:
GPL96 GPL85
66 Samples
Download data: CEL
Series
Accession:
GSE14555
ID:
200014555
7.

Toxicogenomic Comparison of TCDD and PCB 126 Responsiveness in Primary Rat Hepatocytes

(Submitter supplied) (Abstract) Toxicogenomics has great potential for enhancing our understanding of environmental chemical toxicity, hopefully leading to better-informed human health risk assessments. This study employed toxicogenomic technology to reveal species differences in response to two prototypical aryl hydrocarbon receptor (AHR) agonists, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and the polychlorinated biphenyl (PCB) congener PCB 126. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL85
26 Samples
Download data: CEL
Series
Accession:
GSE14554
ID:
200014554
8.

Toxicogenomic Comparison of TCDD and PCB 126 Responsiveness in Primary Human Hepatocytes

(Submitter supplied) (Abstract) Toxicogenomics has great potential for enhancing our understanding of environmental chemical toxicity, hopefully leading to better-informed human health risk assessments. This study employed toxicogenomic technology to reveal species differences in response to two prototypical aryl hydrocarbon receptor (AHR) agonists, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and the polychlorinated biphenyl (PCB) congener PCB 126. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
40 Samples
Download data: CEL
Series
Accession:
GSE14553
ID:
200014553
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