GEO DataSets

Analysis of a metabolically competent liver cell line HepG2 exposed to coplanar PCB-77, a prototype congener of polychlorobiphenyls (PCB). Different congeners of PCB lead to varying degrees of cellular oxidative stress. Results provide insight into the mechanism of action of coplanar PCB congeners.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 4 time sets

Platform:

GPL570

Series:

GSE6878

12 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS3954 GDS3955

Platform:

GPL570

28 Samples

Download data: CEL

(Submitter supplied) Exposure to Polychlorobiphenyls (PCBs) is known to cause serious health effects in human but the gene expression profiles leading to development of different diseases is not fully understood. The knowledge of global gene expression will help us to develop early diagnostic biomarkers for PCB induced health effects. We used microarrays to detail the global gene expression profile underlying the effects of PCB77 on human liver cells leading to identification of distinct classes of up-regulated and down-regulated genes and cellular processes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

12 Samples

Download data: CEL

(Submitter supplied) Exposure to Polychlorobiphenyls (PCBs) is known to cause serious health effects in human but the gene expression profiles leading to development of differnet diseases is not fully understood. The knowledge of global gene expression will help us to devlop early diagnostic biomarkers for PCB induced health effects. We used microarrays to detail the global gene expression profile underlying the effects of PCB153 on human liver cells leading to identification of distinct classes of up-regulated and down-regulated genes and cellular processes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

16 Samples

Download data: CEL

Analysis of a metabolically competent HepG2 cells exposed to PCB-153, a prototype non-coplanar congener of polychlorobiphenyls (PCB). Different congeners of PCB lead to varying degrees of cellular oxidative stress. Results provide insight into the mechanism of action of non-coplanar PCB congeners.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 5 time sets

Platform:

GPL570

Series:

GSE6878

16 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL96 GPL85

66 Samples

Download data: CEL

(Submitter supplied) (Abstract) Toxicogenomics has great potential for enhancing our understanding of environmental chemical toxicity, hopefully leading to better-informed human health risk assessments. This study employed toxicogenomic technology to reveal species differences in response to two prototypical aryl hydrocarbon receptor (AHR) agonists, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and the polychlorinated biphenyl (PCB) congener PCB 126. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

26 Samples

Download data: CEL

(Submitter supplied) (Abstract) Toxicogenomics has great potential for enhancing our understanding of environmental chemical toxicity, hopefully leading to better-informed human health risk assessments. This study employed toxicogenomic technology to reveal species differences in response to two prototypical aryl hydrocarbon receptor (AHR) agonists, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and the polychlorinated biphenyl (PCB) congener PCB 126. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

40 Samples

Download data: CEL