GEO DataSets

Analysis of peripheral blood from MS patients with high or low serum levels of transmembrane-type semaphorin Sema4A. MS patients with high Sema4A levels have more severe disabilities and are unresponsive to IFN-β treatment. Results provide insight into role of Sema4A in the pathogenesis of MS.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 2 genotype/variation sets

Platform:

GPL570

Series:

GSE26484

10 Samples

Download data: CEL

(Submitter supplied) Background: Multiple sclerosis (MS) is a demyelinating autoimmune disease of the central nervous system and the leading cause of lasting neurological disabilities in young adults. Increasing evidence suggests that early treatment prevents the development of disability. However, there have been no reliable serum markers to assist the early diagnosis. In addition, interferon (IFN)-β, which is the major treatment for MS, is not always effective. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4152

Platform:

GPL570

10 Samples

Download data: CEL

(Submitter supplied) IFNβ, an effective therapy against relapsing-remitting (RR) multiple sclerosis (MS) is naturally secreted during the innate immune response against viral pathogens. The objective of this study was to characterize the immunomodulatory mechanisms of IFNβ targeting innate immune response and their effects on DC-mediated regulation of T-cell differentiation. We found that IFNβ−1a in-vitro treatment of human monocyte-derived dendritic cells (DCs) induced the expression of TLR7 and the members of its downstream signaling pathway, including myeloid differentiation factor 88 (MyD88), IL-1R-associated kinase (IRAK)4, and TNF receptor-associated factor (TRAF)6, while it inhibited the expression of IL-1R. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

30 Samples

Download data: CEL

(Submitter supplied) We hypothesized that IL-33 created Tc1-like condition in the modifying tumor microenvironment (TME). RNA-seq analysis of dendritic cells (DCs) showed the elevation of Il1rl1 and SEMA4A by IL-33, the latter of which was confirmed by qPCR, without significant upregulation of IL-12.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

6 Samples

Download data: CSV

(Submitter supplied) Regulation of gene expression in immune cells is known to be under genetic control, and likely contributes to susceptibility to autoimmune diseases, such as multiple sclerosis (MS). How this occurs in concert across multiple immune cell types is poorly understood. Using a mouse model that harnesses the genetic diversity of wild-derived mice, more accurately reflecting genetically diverse human populations, we provide an extensive characterization of the genetic regulation of gene expression in five different naïve immune cell types relevant to MS. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL17543

60 Samples

Download data: TXT