GEO DataSets

Analysis of gut biopsies from HIV+ patients following interruption of HAART. Gut-associated lymphoid tissue (GALT) is a critical host-pathogen interaction site in HIV infection. Results provide insight into molecular basis of host response to viral rebound in GALT following HAART interruption.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 6 individual sets

Platform:

GPL570

Series:

GSE28177

6 Samples

Download data: CEL

(Submitter supplied) We evaluated longitudinal changes in viral replication and emergence of viral variants in the context of T cell homeostasis and gene expression in GALT of three HIV-positive patients who initiated HAART during primary HIV infection but opted to interrupt therapy thereafter. Longitudinal viral sequence analysis revealed that a stable proviral reservoir was established in GALT during primary HIV infection that persisted through early HAART and post-therapy interruption. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4227

Platform:

GPL570

6 Samples

Download data: CEL

(Submitter supplied) HIV is known to severely affect the gastrointestinal immune system, in particular compartments of immunity that regulate gut microbial composition. Furthermore, recent studies in mice have shown that dysregulation of the gut microbiome can contribute to chronic inflammation, which is a hallmark of HIV and is thought to fuel disease progression. We sought to understand whether the gut microbial community differs in HIV-infected subjects, and whether such putative differences are associated with disease progression. more...

Organism:

Homo sapiens; Archaea; Bacteria

Type:

Expression profiling by array

Platform:

GPL16546

34 Samples

Download data: CEL