GEO DataSets

Analysis of MDA-MB-231, MCF7 and PC3 cells treated with lysophosphatidic acid (LPA). LPA activates six different G protein-coupled receptors (LPA receptors 1-6). Results provide insight into LPA-induced genes among three unrelated cancer cell lines expressing different patterns of LPA receptors.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 3 cell line sets

Platform:

GPL570

Series:

GSE56265

12 Samples

Download data: CEL, CHP

(Submitter supplied) LPA is a natural bioactive lipid with growth factor-like functions due to activation of series of six G protein-coupled receptors (LPA1-6). In this study we determine the LPA induced early-gene expression profile in three unrelated human cancer cell lines (MDA-MB-231, MCF7, PC3) with an objective to identify potential biomarker/s specifically upregulated through the activation of LPA receptor type 1 (LPA1)

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4951

Platform:

GPL570

12 Samples

Download data: CEL, CHP

(Submitter supplied) LPA is a natural bioactive lipid with growth factor-like functions due to activation of series of six G protein-coupled receptors (LPA1-6). In this study we determine the LPA induced early-miRNA expression profile in human breast cancer cell lines MDA-MB-231

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platforms:

GPL13264 GPL19263

6 Samples

Download data: TXT

(Submitter supplied) To investigate gene expression changes induced by Lysophosphatidic acid receptor 3 (LPA3) activation in peri-implantation uteri, we performed microarray analysis in LPA3 agonist (T13)-injected pseudopregnant uteri. On 3.5 dpc, pseudopregnant mice were subjected with intrautero-injection of vehicle (0.01% BSA-PBS) or T13 and then uteri were dissected 24-36 hr after the injection. We found that several thousand genes were up- or down-regulated by T13 injection. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10333

6 Samples

Download data: TXT

(Submitter supplied) Identification of the genes whose expression levels are regulated by T13 during peri-implantation period

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL16570

6 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:

GPL28457 GPL24247

14 Samples

Download data: COV

(Submitter supplied) Central nervous system (CNS) resident cells such as microglia, oligodendrocytes and astrocytes are gaining increasing attention in respect to their contribution to CNS pathologies including Multiple Sclerosis (MS). Several studies have demonstrated the involvement of pro- inflammatory glial subsets in the pathogenesis and propagation of inflammatory events in MS and its animal models. However, it has only recently become clear that the underlying heterogeneity of astrocytes and microglia can not only drive inflammation, but also lead to its resolution through direct and indirect mechanisms. more...

Organism:

Mus musculus

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL24247

8 Samples

Download data: COV

(Submitter supplied) Central nervous system (CNS) resident cells such as microglia, oligodendrocytes and astrocytes are gaining increasing attention in respect to their contribution to CNS pathologies including Multiple Sclerosis (MS). Several studies have demonstrated the involvement of pro- inflammatory glial subsets in the pathogenesis and propagation of inflammatory events in MS and its animal models. However, it has only recently become clear that the underlying heterogeneity of astrocytes and microglia can not only drive inflammation, but also lead to its resolution through direct and indirect mechanisms. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28457

6 Samples

Download data: CSV

(Submitter supplied) Cancer Res; 78(2); 399-409. ©2017 The nuclear receptor PPAR-β/δ (PPARD) has essential roles in fatty acid catabolism and energy homeostasis as well as cell differentiation, inflammation, and metabolism. However, its contributions to tumorigenesis are uncertain and have been disputed. Here, we provide evidence of tumor suppressive activity of PPARD in prostate cancer through a noncanonical and ligand-independent pathway. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

9 Samples

Download data: TXT

(Submitter supplied) The aim of this study was to investigate microRNA expression pattern and its functional relevance on the commitment toward mucosal differentiation and on IgE-mediated activation of mast cells. To identify microRNA genes the expression of which change during the differentiation and activation of murine primary mast cells in vitro, the putative committed progenitors (c-kit+ cells isolated on day 6 from differentiating cultures), immature mast cells (BMMC), mucosal-type mast cells (MMC), and IgE-activated mast cells were compared by Agilent microRNA array.

Organism:

Mus musculus

Type:

Non-coding RNA profiling by array

Platform:

GPL8824

16 Samples

Download data: TXT