Similar studies for GEO DataSets (Select 5057) - GEO DataSets

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Items: 2

Select item 50571.

Mepenzolate bromide effect on lung: time course

Analysis of lung up to 25 hrs after a single, intratracheal administration of mepenzolate (MEP). MEP, a muscarinic receptor antagonist, decreases elastase-induced airspace enlargement. Results provide insight into molecular mechanisms underlying the beneficial effect of MEP on airspace enlargement.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 agent, 2 time sets

Platform:: GPL6246
Series:: GSE50836
8 Samples

Download data: CEL

DataSet

Accession:: GDS5057

ID:: 5057

Select item 2000508362.

Mepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary disease

(Submitter supplied) For the clinical treatment of chronic obstructive pulmonary disease (COPD), it is important not only to improve the airflow limitation by bronchodilation but also to suppress emphysema by controlling inflammation. In this study, we have screened for compounds that prevent elastase-induced airspace enlargement in mice from medicines already used clinically. Mepenzolate bromide, a muscarinic antagonist used to treat gastrointestinal disorders was selected. more...