GEO DataSets

Analysis of synovial biopsies from rheumatoid arthritis patients before and 12 weeks after the start of methotrexate (MTX) therapy. Results compared to those obtained from tocilizumab (TCZ) therapy (GDS5068) and provide insight into the differences in the mechanisms of action between TCZ and MTX.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 8 individual sets

Platform:

GPL570

Series:

GSE45867

16 Samples

Download data: CEL

(Submitter supplied) Rheumatoid arthritis (RA) is a chronic, systemic autoimmune inflammatory disease that is characterized by the presence of inflammatory cytokines, including interleukin-6 (IL-6). Here, we investigated the global molecular effects of Tocilizumab, an approved humanized anti-IL6 Receptor antibody, versus Methotrexate therapy, in synovial biopsy samples collected prospectively in early RA before and 12 weeks after administration of the drug. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS5068 GDS5069

Platform:

GPL570

40 Samples

Download data: CEL

(Submitter supplied) Rheumatoid arthritis (RA) is an inflammatory joint disorder that results in progressive joint damage when insufficiently treated. In order to prevent joint destruction and functional disability in RA, early diagnosis and initiation of appropriate treatment with Disease-Modifying Antirheumatic Drugs (DMARDs) is needed. However, in daily clinical practice, patients may initially display symptoms of arthritis that do not fulfil the classification criteria for a definite diagnosis of RA, or any other joint disease, a situation called “Undifferentiated Arthritis” (UA). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4195

Platform:

GPL570

25 Samples

Download data: CEL, CHP

(Submitter supplied) Objective: Rituximab displays therapeutic benefits in the treatment of rheumatoid arthritis (RA) patients resistant to TNF blockade. However, the precise role of B cells in the pathogenesis of RA is still unknown. In this study we investigated the global molecular effects of rituximab in synovial biopsies obtained from anti-TNF resistant RA patients before and after administration of the drug. Methods: Paired synovial biopsies were obtained from the affected knee of anti-TNF resistant RA patients before (T0) and 12 weeks after initiation of rituximab therapy (T12). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4903

Platform:

GPL570

24 Samples

Download data: CEL, CHP

Analysis of synovial biopsies from rheumatoid arthritis patients before and 12 weeks after the start of tocilizumab (TCZ) therapy. Results compared to those obtained from methotrexate (MTX) therapy (GDS5069) and provide insight into the differences in the mechanisms of action between TCZ and MTX.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 12 individual sets

Platform:

GPL570

Series:

GSE45867

24 Samples

Download data: CEL

Analysis of synovial biopsy samples from anti-TNF resistant rheumatoid arthritis (RA) patients 12 wks after the start of rituximab (RTX) therapy. RTX is a mAb against CD20, expressed on subsets of B cells. Results provide insight into how RTX-induced B cell depletion interferes with RA pathogenesis.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 12 individual sets

Platform:

GPL570

Series:

GSE24742

24 Samples

Download data: CEL, CHP

Analysis of synovial biopsies obtained by needle arthroscopy from affected knees of patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), or osteoarthritis (OA). Results provide insight into distinct molecular mechanisms underlying SLE arthritis relative to those of OA and RA.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 5 disease state, 2 gender sets

Platform:

GPL570

Series:

GSE36700

25 Samples

Download data: CEL, CHP

(Submitter supplied) TNFalpha and IL1beta play a pathogenic role in rheumatoid arthritis. Both cytokines are known to activate cytokine and metalloproteinase secretion by synovial fibroblasts. In the present study, we wanted to investigate whether TNFalpha and IL1beta displayed differential effects on cultured Fibroblast-like Synovial Cells derived from RA patients. Global gene expression analyses indicated that both cytokines induced similar genes in these cells.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

6 Samples

Download data: CEL

(Submitter supplied) TNF antagonists are routinely used in severe rheumatoid arthritis (RA) patients who failed conventional DMARD therapy. According to large clinical trials, the three available drugs (adalimumab, infliximab and etanercept) display similar effects in terms of efficacy, tolerability and side effects. These studies also indicate that about 25% of RA patients treated with TNF-antagonists do not display any significant clinical improvement. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

11 Samples

Download data: CEL

(Submitter supplied) Gene expression profiles in synovial biopsies from patients with rheumatoid arthritis (RA) display a high level of plasticity related to disease activity and response to therapy. In order to identify TNFa-dependent genes in ex vivo RA or other synovial biopsies, we generated the present set of data using primary fibroblast-like synovial cell (FLS) cultures incubated overnight in the presence or the absence of TNFa.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

4 Samples

Download data: CEL

(Submitter supplied) Our goal was to assess for the histological and transcriptomic effects of Abatacept on RA synovia, and to compare them with previously published data from four other DMARDs: Tocilizumab, Rituximab, Methotrexate and Adalimumab.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

20 Samples

Download data: CEL

(Submitter supplied) Total RNA sequencing was performed on samples isolated from joint synovial biopsies from subjects with rheumatoid arthritis before and after 6 months of triple DMARD treatment

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11154

38 Samples

Download data: TXT

(Submitter supplied) Total RNA sequencing was performed on samples isolated from joint synovial biopsies from subjects with and without rheumatoid arthritis

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11154

218 Samples

Download data: TXT

(Submitter supplied) The aim of this study was to identify the specific molecular biological features predicting the therapeutic outcomes of three bDMARDs, infliximab (IFX), tocilizumab (TCZ), and abatacept (ABT) by studying blood gene expression signature of patients prior to biologic treatment in a unified test platform. GSEA analyses showed that inflammasome genes were significantly upregulated in IFX’s NON-REM compared with its REM. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6480

209 Samples

Download data: TXT

(Submitter supplied) Spots were selected that had an expression level higher than 1.6 the local background. The use of a common reference sample allows the comparison of the relative expression levels across the tissue samples. All genes were expressed relative to their median expression level across the arrays of the same microarray platform, allowing us to combine the data from the 2 platforms. Data from Lymphochip and Stanford Human cDNA arrays was combined per patient. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

4 related Platforms

28 Samples

Download data

(Submitter supplied) The aim of this study was to compare gene expression between two pathological groups of human synovial fibroblasts (SF) from rheumatoid arthritis (RA) and osteoarthritis (OA) synovial tissues with normal SF from healthy individuals (HSF). We used microarray expression profiling in SF cultured from OA, RA and normal synovial tissues. We found larger numbers of transcripts with differential expression in OASF compared to the other groups than in RASF compared to HSF. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4133

31 Samples

Download data: TXT

(Submitter supplied) Background: Although the use of TNF inhibitors has fundamentally changed the way rheumatoid arthritis (RA) is treated, not all patients respond well. It is desirable to facilitate the identification of responding and non-responding patients prior to treatment, not only to avoid unnecessary treatment but also for financial reasons. In this work we have investigated the transcriptional profile of synovial tissue sampled from RA patients before anti-TNF treatment with the aim to identify biomarkers predictive of response. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL7768

62 Samples

Download data: GPR

(Submitter supplied) Rheumatoid arthritis (RA) leads to progressive destruction of articular structures. Despite recent progress in controlling inflammation and pain, little cartilage repair has yet been observed. This in vitro study aims to determine the role of chondrocytes in RA-related cartilage destruction and antirheumatic drug-related regenerative processes. Human chondrocytes were three-dimensionally cultured in alginate beads. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

20 Samples

Download data: CEL, EXP, TXT

(Submitter supplied) mRNA expression levels in synovial fibroblasts in 6 rheumatoid arthritis patients versus 6 osteoarthritis patients. Keywords: disease type comparison, mRNA expression study

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2931

Platform:

GPL8300

12 Samples

Download data: CEL, CHP

Comparison of synovial fibroblasts from patients with rheumatoid arthritis (RA) to those with osteoarthritis (OA). RA is characterized by chronic inflammation and destruction of multiple joints. OA is a degenerative disease resulting from the breakdown of cartilage.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 other sets

Platform:

GPL8300

Series:

GSE7669

12 Samples

Download data: CEL, CHP