GEO DataSets

Analysis of prostate cancer cells microdissected from high grade prostate cancer tumor samples. Results identify a gene expression signature for high grade prostate cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 3 other sets

Platform:

GPL570

Series:

GSE45016

11 Samples

Download data: CEL

(Submitter supplied) We identified a novel molecular target and diagnostic biomarker, SHISA2, as an overexpressed gene in high-grade prostate cancer (PC) cells. To understand the association of SHISA2 overexpression with the aggressiveness of high-grade PC, we performed gene expression analysis using a cDNA microarray.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

2 Samples

Download data: CEL

(Submitter supplied) To identify molecules to serve as diagnostic markers for high-grade prostate cancer (PC) and targets for novel therapeutic drugs, we investigated the gene expression profiles of high-grade PCs using a cDNA microarray combined with laser microbeam microdissection.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5072

Platform:

GPL570

11 Samples

Download data: CEL

(Submitter supplied) To characterize the molecular features of clinical (Hormone-Refractory Prostate Cancers) HRPCs, we generated the precise gene-expression profiles of 25 clinical HRPCs and 10 hormone-sensitive prostate cancers (HSPCs) by genome-wide cDNA microarrays combining with laser microbeam microdisection. Keywords: disease status analysis

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4747

35 Samples

Download data: TXT

(Submitter supplied) To identify molecular changes that occur during prostate tumor progression, we have characterized a series of prostate cancer cell lines isolated at different stages of tumorigenesis from C3(1)/Tag transgenic mice.

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array

Platform:

GPL20562

19 Samples

Download data: GPR

(Submitter supplied) Patients with high-risk localized prostate cancer (tumor-node-metastasis ≥ T2b or prostate-specific antigen ≥ 15 ng/mL or Gleason glade ≥ 4+3) were enrolled into a phase II clinical trial of neoadjuvant chemotherapy with docetaxel and mitoxantrone followed by prostatectomy. Pretreatment prostate tissue was acquired by needle biopsy and posttreatment tissue was acquired by prostatectomy. Prostate epithelium was captured by microdissection, and transcript levels were quantitated by cDNA microarray hybridization.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL4767 GPL4763

31 Samples

Download data: TXT

(Submitter supplied) To better understand the molecular mechanism that underlay tumorigenesis and progression of prostate cancer (PCa), we studied the gene expression profiles of sixteen PCa compared to their matched normal tissues. Using Significance Analysis of Microarrays, we identified 53 genes differentially expressed that were more than 2 fold up- or down-regulated in at least 50 % of the tumors. Keywords: disease state analysis

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1998

16 Samples

Download data: GPR

(Submitter supplied) We identified a novel lipogenic gene, ELOVL7, as an over-expressed gene in prostate cancer (PC) cells and it is involved in elongation of long-chain fatty acids and can play some important roles in prostate carcinogenesis. To investigate into downstream pathways of ELOVL7, we performed the gene expression analysis by the genome-wide cDNA microarrays. The genome–wide gene expression patterns were compared between PC cells transfected with siELOVL7 and these with siCONTROL and between the ELOVL7-overexpressing in-vivo tumors in mice bread with high fat diet (HFD) and those with normal diet (ND). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4747

6 Samples

Download data

(Submitter supplied) Plasma cells (PCs) as effectors of humoral immunity produce immunoglobulins to match pathogenic insult. However, emerging data suggests more diverse roles for PCs as regulators of immune and inflammatory responses via secretion of factors other than immunoglobulins. The extent to which such responses are pre-programmed in B-lineage cells or can be induced in PCs by the microenvironment is unknown. Here we dissect the impact of IFNs on the regulatory networks of human plasma cells. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

63 Samples

Download data: TXT