GEO DataSets

Analysis of liver from ob/ob obese males given water with 1 mg/L each of 11 drugs during 4 months. Contamination of drinking water with these drugs may have harmful effects on health. Results provide insight into mechanisms underlying obese liver responses to water-borne drug contamination.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets

Platform:

GPL7202

Series:

GSE49195

24 Samples

Download data: TXT

(Submitter supplied) BACKGOUND: Drinking water can be contaminated with pharmaceuticals. However, it is uncertain whether this contamination can have harmful consequences for the liver, especially in the context of obesity. OBJECTIVES: To determine whether chronic, low dose exposure to pharmaceuticals could have deleterious effects in livers of lean and obese mice. METHODS: Lean and ob/ob male mice (5-week-old) were treated for 4 months with a mixture of 11 drugs (acetaminophen, caffeine, carbamazepine, cotinine, diclofenac, erythromycin, ibuprofen, phenazone, roxithromycin, salicylic acid and sulfamethoxazole) provided in drinking water at a concentration of 1 mg/L (for each drug). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5258

Platform:

GPL7202

24 Samples

Download data: TXT

(Submitter supplied) Animal studies have linked disturbed adipose tissue clock gene rhythms to the pathophysiology of the metabolic syndrome. However, data on molecular clock rhythms in human patients are limited. Therefore, in a standardized real life setting, we compared diurnal gene expression profiles in subcutaneous adipose tissue between obese patients with type 2 diabetes and age-matched healthy lean control subjects, using RNA sequencing. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16558

48 Samples

Download data: TXT, XLSX

(Submitter supplied) The circadian clock system coordinates metabolic, physiological, and behavioral functions across a 24-hour cycle, crucial for adapting to environmental changes. Disruptions in circadian rhythms contribute to major metabolic pathologies like obesity and Type 2 diabetes. Understanding the regulatory mechanisms governing circadian control is vital for identifying therapeutic targets. It is well characterized that chromatin remodeling at distal enhancer elements shapes the genome topology, supporting rhythmic transcriptional cycles; yet the impact of rhythmic chromatin topology and circadian enhancers in disease states is largely unexplored. more...

Organism:

Mus musculus

Type:

Other

Platforms:

GPL17021 GPL16417

48 Samples

Download data: BEDGRAPH

(Submitter supplied) To determine the effects of age and lipoic acid supplementation on hepatic gene expression, we fed young (3 months) and old (24 months) male Fischer 344 rats a diet with or without 0.2% (w/w) R-α-lipoic acid (LA) for two weeks. Total RNA isolated from liver tissue was analyzed by Affymetrix microarray to examine changes in transcriptional profile. Results showed an increase in pro-inflammatory gene expression in the aging liver, with increased immune cell function and tissue remodeling genes, representing 45% of the age-related transcriptome changes. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

30 Samples

Download data: CEL

(Submitter supplied) Exposure to high levels of arsenic in drinking water is associated with several types of cancers including lung, bladder and skin, as well as vascular disease and diabetes. Drinking water standards are based primarily on epidemiology and extrapolation from higher dose experiments, rather than measurements of phenotypic changes associated with chronic exposure to levels of arsenic similar to the current standard of 10ppb, and little is known about the difference between arsenic in food as opposed to arsenic in water. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3801

Platform:

GPL1261

55 Samples

Download data: CEL, CHP

Analysis of lungs of C57BL/6 males, on defined diets, chronically exposed to environmentally relevant concentrations of arsenic (As) in food or drinking water. Acute exposure to As through intraperitoneal injection also examined. Results provide insight into the basis of As toxicity from ingestion.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 5 agent, 4 dose, 2 growth protocol, 4 protocol sets

Platform:

GPL1261

Series:

GSE11056

55 Samples

Download data: CEL, CHP

(Submitter supplied) Ibuprofen is one of the most commonly detected pharmaceuticals in wastewater effluent; however the effects of ibuprofen on aquatic organisms are poorly understood. This study presents the transcriptome-wide response of the inland silverside, Menidia beryllina, to chronic 14 d exposures to ibuprofen.

Organism:

Menidia beryllina

Type:

Expression profiling by array

Platform:

GPL19653

24 Samples

Download data: TXT

(Submitter supplied) We tested if psychoactive pharmaceuticals (fluoxetine, carbamazapine, venlafaxine) at lower concentrations (in ppb) could induce gene expressions linked with neurological disoders.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL15520

3 Samples

Download data: TXT

(Submitter supplied) Mice injected IP with 5'-AMP enter a hypometabolic state that is an induced hybernation (AIHM). Recovery from this AIHM is marked by reverse flip (RF) behavior Illumina arrays were used to profile control, AIHM and RF aminals in RNA prepared from the liver.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

11 Samples

Download data: TXT