GEO DataSets

Analysis of fatty acid (FA)-loaded macrophages stimulated with bacterial lipopolysaccharide (LPS). LPS is a Toll-like receptor 4 (TLR4) agonist. Results provide insight into the molecular mechanisms that promote triglyceride retention in LPS-exposed macrophages.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 4 other, 4 protocol sets

Platform:

GPL6887

Series:

GSE42190

15 Samples

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(Submitter supplied) When macrophages are activated by sensing bacterial lipopolysaccharides (LPS), they greatly increase their motility, mRNA synthesis and protein production. Most of the ATP needed for these responses is derived from the uptake and catabolism of glucose, a relatively inefficient ATP source. Although the stimulated cells also increase their uptake of free fatty acids, they store a large fraction as triglycerides (TAG). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5311

Platform:

GPL6887

15 Samples

Download data: TXT

(Submitter supplied) The study was designed to investigate the acute effects of B2AR receptor activation on global gene expression changes in bone marrow-derived macrophages. Fenoterol was chosen as B2AR agonist, but our earlier experiments using B2AR antagonists and B2AR knockout cells indicated that norepinephrine signal predominantly via B2AR in macrophages.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21103

12 Samples

Download data: TSV

(Submitter supplied) The aim of this study was to investigate the effects of hypoxia on human macrophages Keywords: Effect of treatment

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2036

Platform:

GPL91

4 Samples

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Expression profiling of cultured macrophages subjected to hypoxia for 24 hours. Macrophages were derived from the mononuclear cells of 4 healthy donors.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 stress sets

Platform:

GPL91

Series:

GSE4630

4 Samples

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(Submitter supplied) Macrophages stimulated with lipopolysaccharide (LPS) plus interferon-g (IFNg) accumulate TGs in LDs, and long-chain acylcarnitines. Inhibition of TG synthesis results in diminished LD development, and increased long chain acylcarnitine levels, suggesting that FA fate is balanced between TG and acylcarnitine synthesis. Nevertheless, TG-synthesis is required for inflammatory macrophage function, since its inhibition negatively affects production of proinflammatory IL-1b, IL-6 and PGE2, and phagocytic capacity, and protects against LPS-induced sock in vivo.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21493

12 Samples

Download data: TXT

(Submitter supplied) Adoption of Warburg metabolism is critical for macrophage activation in response to lipopolysaccharide (LPS). Macrophages stimulated with LPS (without or with interferon-γ) increase expression of nicotinamide phosphoribosyltransferase (NAMPT), a key enzyme in NAD+ salvage, and loss of NAMPT activity alters their inflammatory potential. However, events leading to NAD+ salvage-dependence in these cells remain poorly defined. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21493

24 Samples

Download data: TXT