GEO DataSets

Analysis of bronchial epithelial cell lines 16HBE14o- (Hla-susceptible) and S9 (Hla-resistant) treated with S. aureus recombinant alpha-toxin (rHla) for 2 hrs. Results provide insight into molecular mechanisms underlying cell type-specific responses of airway epithelial cells to alpha-toxin.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 2 cell line sets

Platform:

GPL6244

Series:

GSE65018

8 Samples

Download data: CEL

(Submitter supplied) Responsiveness of cells to alpha-toxin (Hla) from Staphylococcus aureus appears to occur in a cell-type dependent manner. Here, we compare two human bronchial epithelial cell lines, i.e. Hla-susceptible 16HBE14o- and Hla-resistant S9 cells, by a quantitative multi-omics strategy for a better understanding of Hla-induced cellular programs. Phosphoproteomics revealed a substantial impact on phosphorylation-dependent signaling in both cell models and highlights alterations in signaling pathways associated with cell-cell and cell-matrix contacts as well as the actin cytoskeleton as key features of early rHla-induced effects. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5812

Platform:

GPL6244

8 Samples

Download data: CEL

(Submitter supplied) Profiling of MCF-7 cell lines stably overexpressing constitutively active Raf-1, constitutively active MEK, constitutively active c-erbB-2, or ligand-activatable EGFR as models of overexpressed growth factor signaling, as well as control vector transfected cells (coMCF-7) and control vector transfected cells long-term adapted for estrogen-independent growth (coMCF-7/lt-E2). Keywords: Cell Line Comparison

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1925

Platform:

GPL96

18 Samples

Download data: CEL

Analysis of estrogen receptor (ER) alpha positive MCF-7 breast cancer cells overexpressing constitutively active Raf-1, constitutively active MEK, constitutively active c-erbB-2, or ligand-activatable EGFR. Results indicate that increased MAPK activation results in loss of ER-alpha expression.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 6 cell line sets

Platform:

GPL96

Series:

GSE3542

18 Samples

Download data: CEL