Similar studies for GEO DataSets (Select 717) - GEO DataSets

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Items: 4

Select item 7171.

Huntingtons disease and combination drug therapy

Whole brain hemispheres from Huntingtons disease model R6/2 transgenic mice treated with creatine, tacrine and moclobemide from 5 weeks of age. Drug therapy was aimed at boosting neurotransmitter levels and improve cognitive functions.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 agent, 2 strain sets

Platform:: GPL81
Series:: GSE857
13 Samples

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DataSet

Accession:: GDS717

ID:: 717

Select item 2000008572.

Triple treatment R6/2 mice

(Submitter supplied) Huntington’s disease is a genetic disease caused by a single mutation. It is characterised by progressive movement, emotional and cognitive deficits. R6/2 transgenic mice carrying the Huntington’s disease mutation have a progressive neurological phenotype, including deterioration in cognitive function. The mechanism underlying the cognitive deficits in R6/2 mice is unknown, but dysregulated gene expression, reduced neurotransmitter levels and abnormal synaptic function are present before the cognitive decline becomes pronounced. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS717
Platform:: GPL81
13 Samples

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Series

Accession:: GSE857

ID:: 200000857

Select item 2000036213.

R6/1 brain hemisphere time series gene expression

(Submitter supplied) HD R6/1 transgenic mouse line brain hemispheres dissected. RNA targets were created for transgenics and wildtypes at time points 18, 22 and 27 weeks. Profiles and data analysis performed using the Bioconductor software and linear model contrasts using LIMMA on RMA probeset summarys. Keywords: timecourse

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS2912
Platform:: GPL1261
18 Samples

Download data: CEL

Series

Accession:: GSE3621

ID:: 200003621

Select item 29124.

Huntington's disease transgenic model: time course

Analysis of brains of R6/1 transgenic animals at 18 to 27 weeks of age. The R6/1 transgenic animal expresses exon 1 of the mutant human huntingtin gene that contains 115 CAG trinucleotide repeats. Results provide insight into the early pathogenesis of HD.