GEO DataSets

Analysis of OT-I CD8+ T cells from lymphopenic C57BL/6s. OT-I CD8+ T cells transferred into C57BL/6s, irradiated to induce lymphopenia. OT-I CD8+ T cells examined at various time points up to 115 days after transfer. Results provide insight into mechanisms regulating homeostatic proliferation.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 protocol, 3 time sets

Platform:

GPL81

Series:

GSE1921

19 Samples

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(Submitter supplied) A time course of OTI CD8 T cells transferred to irradiated syngeneic hosts (or unirradiated hosts as control). Keywords: time-course

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS993

Platform:

GPL81

19 Samples

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(Submitter supplied) Our earlier study demonstrated that when CFSE-labeled LCMV-or Pichinde virus-immune spleen leukocytes were transferred into T cell-deficient hosts, the bona fide virus-specific memory cells underwent relatively limited cell division and were substantially diluted in frequency by other more extensively proliferating cells originating from that donor cell population. We questioned how the slowly dividing population, which contained bona fide memory cells, differed from the rapidly dividing cells, which contained “memory-like” cells. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

2 Samples

Download data: CEL, CHP, EXP

(Submitter supplied) The generation of marginal zone (MZ) B cells is a Notch2 dependent process. We observed that transdifferentiation of follicular (FO) B cells to an MZ-like phenotype is dependent on a lymphopenic environment. We therefore adoptively transftered congenically marked SJL.C20 (CD45.1) mature naive FO B cells into either lymphopenic Rag2-/- or intact C57BL6 (CD45.2) recipient mice and recovered and double sorted intermediate phenotype (MZ-FO) donor B cells at day 4 post transfer from Rag2-/- recipients or both MZ and FO phenotype donor B cells at day 8 post transfer from both recipient groups and performed RNA sequencing.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

27 Samples

Download data: TXT