GEO DataSets

(Submitter supplied) High cholesterol diet and xenobiotic treatment induce changes in cholesterol homeostasis and drug metabolism. Mice were either 7 days on high cholesterol diet or were treated with phenobarbital. Liver samples were anayzed using Affymetrix GeneChip MOE430A. Keywords: treatment and diet effects

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3103

Platform:

GPL339

12 Samples

Download data: CEL, EXP

(Submitter supplied) High cholesterol diet and xenobiotic treatment induce changes in cholesterol homeostasis and drug metabolism. Mice were either 7 days on high cholesterol diet or were treated with phenobarbital. Liver samples were analyzed using Sterolgene v0 cDNA microarrays. Sterolgene microarray is a tool designed to enable focused studies of cholesterol homeostasis and drug metabolism. We show that one week of cholesterol diet down-regulates cholesterol biosynthesis and up-regulates xenobiotic metabolism (Cyp3 family). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4588

8 Samples

Download data: TXT

(Submitter supplied) Pathenogenesis of atherosclerosis results from the interactions between disrupted lipid homeostasis and immune response, but the molecular bridges between the major players are still a matter of controversy. We performed a systemic study of the imflammatory cytokine tumor necrosis factor alpha (TNF alpha), a well established anorexia agent, in the livers of the mice exposed to 20h-cytokine/starvation. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4588

6 Samples

Download data: TXT

(Submitter supplied) Pathogenesis of atherosclerosis results from the interactions between disrupted lipid homeostasis and immune response but the molecular bridges between the major players are still a matter of controversy. We investigated the systemic effect of inflammatory cytokine tumor necrosis factor alpha (TNF-α), a well established anorexia agent, in livers of mice exposed to 24h-cytokine/starvation. 10% of genes of the Agilent 10kb cDNA array is detected above level of detection in the mouse liver. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL872

4 Samples

Download data

Analysis of livers from animals treated with phenobarbital or fed a high cholesterol diet for 7 days. Results provide insight into the molecular mechanisms underlying the effects of these exogenous sources on cholesterol homeostasis and drug metabolism.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 agent sets

Platform:

GPL339

Series:

GSE6721

12 Samples

Download data: CEL, EXP