GEO DataSet Links for PMC (Select 2396576) - GEO DataSets

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Items: 2

Select item 2000101231.

Progerin-induced changes in gene expression

(Submitter supplied) The premature aging disease Hutchinson-Gilford Progeria Syndrome (HGPS) is caused by constitutive production of progerin, a mutant form of the nuclear architectural protein lamin A1. Progerin is also sporadically expressed in wild type cells and has been linked to physiological aging. HGPS cells exhibit extensive nuclear defects including abnormal chromatin structure and increased DNA damage. At the organismal level, HGPS affects several tissues particularly of mesenchymal origin. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3495
Platform:: GPL2895
12 Samples

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Accession:: GSE10123

ID:: 200010123

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 34952.

Progerin expression in a hTERT-immortalized skin fibroblast cell line: time course

Analysis of skin fibroblasts induced to express GFP-progerin for up to 10 days. Progerin is a mutant form of lamin A and the causal agent of premature-ageing disease Hutchinson-Gilford Progeria Syndrome (HGPS). Results provide insight into molecular mechanisms underlying this pathological effect.