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Items: 2

1.

Onconase Responsive Genes in Human Mesothelioma Cells: Implications for an RNA Damaging Therapeutic Agent

(Submitter supplied) Onconase represents a new class of RNA-damaging drugs. Mechanistically, Onconase is thought to internalize, where it degrades intracellular RNAs such as tRNA and double-stranded RNA, and thereby suppresses protein synthesis. However, there may be additional or alternative mechanism(s) of action. Microarray analysis was used to compare gene expression profiles in untreated human malignant mesothelioma (MM) cell lines and cells exposed to 5 ug/ml Onconase for 24 h.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3759
Platform:
GPL570
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE17009
ID:
200017009
2.
Full record GDS3759

Onconase effect on mesothelioma cells in vitro

Analysis of malignant mesothelioma (MM) cell lines (M25, M29, and M49) exposed to Onconase for 24 hrs. Onconase, an RNA damaging therapeutic agent, induces apoptosis in MM cells. Results provide insight into the molecular mechanisms underlying Onconase action in MM.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 3 cell line sets
Platform:
GPL570
Series:
GSE17009
6 Samples
Download data: CEL, CHP

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