(Submitter supplied) Normal cells require continuous exposure to growth factors, in order to cross a restriction point and commit to cell cycle progression. This can be replaced by two short, appropriately spaced pulses of growth factors, where the first pulse primes a process, which is completed by the second pulse, and enables restriction point crossing. Through integration of comprehensive proteomic and transcriptomic analyses of each pulse, we identified three processes that regulate restriction point crossing: (i) The first pulse induces essential metabolic enzymes and activates p53-dependent restraining processes.
more...- Organism:
- Homo sapiens
- Type:
- Expression profiling by array
- Dataset:
-
GDS4362
- Platform:
- GPL6244
- 17 Samples
Download data: CEL