GEO DataSet Links for PMC (Select 3204388) - GEO DataSets

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Links from PMC

Items: 3

Select item 2000379551.

ERa-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL570 GPL9115
14 Samples

Download data: CEL, CHP, TXT

Series

Accession:: GSE37955

ID:: 200037955

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000273002.

Estrogen-independent genomic ER binding analysis

(Submitter supplied) Hormone-independent breast cancer cells (MCF-7/LTED and HCC-1428/LTED) were analyzed by ChIP-seq for estrogen receptor a to identify ER-DNA binding events that occur in the absence of estrogens.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9115
2 Samples

Download data: TXT

Series

Accession:: GSE27300

ID:: 200027300

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000225333.

Breast cancer cells resistant to hormone deprivation maintain an estrogen receptor alpha-dependent, E2F-directed transcriptional program

(Submitter supplied) A significant fraction of breast cancers exhibit de novo or acquired resistance to estrogen deprivation. To model resistance to aromatase inhibitor (AI) therapy, long-term estrogen-deprived (LTED) derivatives of MCF-7 and HCC-1428 cells were generated through culture for 3 and 7 months under hormone-depleted conditions, respectively. These LTED cells showed sensitivity to the ER downregulator fulvestrant under hormone-depleted conditions, suggesting continued dependence upon ER signaling for hormone-independent growth. more...