GEO DataSet Links for PMC (Select 3312333) - GEO DataSets

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Items: 2

Select item 2000336191.

Methylphenidate exposure induces dopamine neuron loss and activation of microglia in the basal ganglia of mice

(Submitter supplied) Background: Methylphenidate (MPH) a psychostimulant prescribed to manage ADHD symptoms, has been increasingly prescribed to children not meeting the strict criteria for ADHD. It has also been misused as a “cognitive enhancer” and as an alternative to other psychostimulants. Here, we investigate whether chronic or acute administration of methylphenidate in mice at either 1mg/kg or 10mg/kg dosing, affects cell number and gene expression in the basal ganglion. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS5497
Platform:: GPL11180
9 Samples

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Accession:: GSE33619

ID:: 200033619

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 54972.

Methylphenidate effect on substantia nigra: dose response

Analysis of substantia nigra from animals treated on weekdays with 1 and 10 mg/kg methylphenidate (MPH) for 3 months. MPH is a psychostimulant used for the treatment of ADHD and narcolepsy. Results provide insight into the neurodegenerative consequences of MPH usage.