GEO DataSets

(Submitter supplied) Cancer cells exhibit an aberrant metabolism which facilitates more efficient production of biomass, and hence tumor growth and progression. The genetic cues modulating this metabolic switch remain largely undetermined, however. Here we identify a metabolic function for PML which reveals an unexpected role for this bona-fide tumor suppressor in pro-survival activity in breast cancer. We find that PML acts as both a negative regulator of PGC1A acetylation and as a potent activator of peroxisome proliferator-activated receptor (PPAR) signaling and fatty acid oxidation (FAO). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4771

Platform:

GPL11180

12 Samples

Download data: CEL, CHP

Analysis of livers from promyelocytic leukemia (Pml)-knockouts fed a high fat diet (HFD) for 20 wks. The increased predisposition of Pml-KOs to HFD-induced obesity is associated with aspects of metabolic syndrome. Results provide insight into molecular basis of a metabolic prosurvival role for PML.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets

Platform:

GPL11180

Series:

GSE39220

12 Samples

Download data: CEL, CHP