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Molecular Signatures Underlying Selective Regional Vulnerability to Alzheimer's Disease

(Submitter supplied) Alzheimer's disease (AD) is the most common form of dementia, characterized by progressive cognitive impairment and neurodegeneration as a result of abnormal neuronal loss. To elucidate the molecular systems associated with AD, we characterized the gene expression changes associated with multiple clinical and neuropathological traits in 1,053 postmortem brain samples across 19 brain regions from 125 persons dying with varying severities of dementia and variable AD-neuropathology severities.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL570 GPL97 GPL96
2004 Samples
Download data: CEL
Series
Accession:
GSE84422
ID:
200084422

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