GEO DataSet Links for PMC (Select 9013128) - GEO DataSets

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Items: 3

Select item 2001723861.

PBAF complex deficiency in melanoma mediates BAF occupancy and transcription factor dynamics

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
70 Samples

Download data: BW

Series

Accession:: GSE172386

ID:: 200172386

PubMed Full text in PMC Similar studies

Select item 2001723842.

PBAF complex deficiency in melanoma mediates BAF occupancy and transcription factor dynamics (RNA-Seq)

(Submitter supplied) ARID2 is an essential subunit of the SWI/SNF PBAF chromatin remodeler and is highly mutate in melanoma. To elucidate the role of ARID2 in melanoma biology and chromatin structure we utilized CRISPR Cas9 methodology to generate isogenic ARID2 WT and KO melanoma clonal cell lines. We further map the genomic localization of several SWI/SNF subunits, open and repressed chromatin markers, and multiple transcription factors to characterize how loss of the PBAF subcomplex alters chromatin accessibility and the melanoma transcription factor network. more...