txid7496[Organism] - GEO DataSets

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Select item 2002711871.

Small RNA sequencing based identification of miRNAs in Cnaphalocrocis medinalis

(Submitter supplied) This study analyzed the expression profiles of miRNAs in fifth instar larvae and pupae of the rice leaf folder (Cnaphalocrocis medinalis) using high-throughput sequencing technology. Furthermore, it predicted the target genes of significantly differentially expressed miRNAs and performed functional enrichment analysis.

Organism:: Cnaphalocrocis medinalis

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL34666
6 Samples

Download data: XLS

Series

Accession:: GSE271187

ID:: 200271187

Select item 2002191522.

Nucleoporin Elys attaches peripheral chromatin to the nuclear pores in interphase nuclei

(Submitter supplied) Transport of macromolecules through the nuclear envelope (NE) is mediated by nuclear pore complexes (NPCs) consisting of nucleoporins (Nups). Elys/Mel-28 is the Nup that binds and connects the decondensing chromatin with the reassembled NPCs at the end of mitosis. Whether Elys links chromatin with the NE during interphase is unknown. Using DamID-seq, we identified Elys binding sites in Drosophila late embryos and divided them into those associated with nucleoplasmic or NPC-linked Elys. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL17275 GPL25244
10 Samples

Download data: BED, BEDGRAPH, SF, XLSX

Series

Accession:: GSE219152

ID:: 200219152

PubMed Full text in PMC Similar studies

Select item 2002707943.

A mechanically regulated liquid-liquid phase separation of the transcriptional regulator Tono instructs muscle development

(Submitter supplied) Muscle morphogenesis is a multi-step program, starting with myoblast fusion, followed by myotube-tendon attachment and sarcomere assembly, with subsequent sarcomere maturation, mitochondrial amplification and specialisation. The correct chronological order of these steps requires precise control of the transcriptional regulators and their effectors. How this regulation is achieved during muscle development is not well understood. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17275
8 Samples

Download data: TXT, XLSX

Series

Accession:: GSE270794

ID:: 200270794

Select item 2002634474.

A Pvr–AP-1–Mmp1 signaling pathway is activated in astrocytes upon traumatic brain injury

(Submitter supplied) Traumatic brain injury (TBI) caused by external mechanical forces is a major health burden worldwide, but the underlying mechanism in glia remains largely unclear. We report herein that Drosophila adults exhibit a defective blood-brain-barrier (BBB), elevated innate immune responses, and appear to be hypertrophy of astrocytes upon consecutive strikes with a high-impact trauma device. RNA sequencing (RNA-seq) analysis of these astrocytes revealed upregulated expression of genes encoding PDGF and VEGF receptor-related (Pvr, a receptor tyrosine kinase (RTK)), adaptor protein complex 1 (AP-1, a transcription factor complex of the c-Jun N-terminal Kinase (JNK) pathway) composed of Jun-related antigen (Jra) and kayak (kay), and matrix metalloproteinase 1 (Mmp1) following TBI. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17275
15 Samples

Download data: TXT

Series

Accession:: GSE263447

ID:: 200263447

Select item 2002363125.

RpS19a depletion alters the haematopoietic translatome to directly drive tissue overgrowth

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL19132 GPL17275
18 Samples

Download data: TXT

Series

Accession:: GSE236312

ID:: 200236312

Select item 2002363106.

RpS19a depletion alters the haematopoietic translatome to directly drive tissue overgrowth II

(Submitter supplied) Counterintuitively, increased tumour predisposition is associated with ribosomal protein (RP) loss. Here, we provide the first evidence that RP depletion can directly drive tissue overgrowth. Haematopoietic compartment-specific knockdown (KD) of RpS19a in the Drosophila lymph gland not only results in haematopoietic stem and progenitor cell (HSPC) loss but also drives excess proliferation and tissue overgrowth. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17275
6 Samples

Download data: TXT, XLSX

Series

Accession:: GSE236310

ID:: 200236310

Select item 2002363077.

RpS19a depletion alters the haematopoietic translatome to directly drive tissue overgrowth I

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19132
12 Samples

Download data: TXT, XLSX

Series

Accession:: GSE236307

ID:: 200236307

Select item 2002709118.

Transcriptome comparison of wild-tyle (w1118) vs. actβ mutants (act80/act4E) Drosophila larvae

(Submitter supplied) TGFβ/Activin subfamilies of ligands. In Drosophila the TGFβ/Activin branch includes three ligands, Myoglianin (Myo), Activin-β (Actβ) and Dawdle (Daw). All three ligands signal through the same type I receptor, Baboon, in conjunction with a type II receptor, Punt or Wit. Baboon has three distinct splice isoforms, termed Babo A, Babo B and Babo C, that differ only in exon 4, which encodes the ligand binding domain. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30203
11 Samples

Download data: XLSX

Series

Accession:: GSE270911

ID:: 200270911

Select item 2002707079.

Deficiency of gut-enriched Lipase H promotes gut aging and reduces lifespan in Drosophila

(Submitter supplied) Liph, a gut-enriched Lipase H encoding gene, shows decreased expression during gut aging in both fruit fly and mouse. However, whether such evolutionary conserved Liph plays a protective role in gut aging remains unknown. In this study, RNA-seq was performed on gut tissue from fly model to identify changes in gene expression produced in whole guts after knocking down CG6295, the Drosophila ortholog of the mammalian Liph. more...

Organism:: Drosophila melanogaster; Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL25947 GPL25244
15 Samples

Download data: TXT

Series

Accession:: GSE270707

ID:: 200270707

Select item 20024519210.

Transcriptomic analysis of Drosophila leg disc associated myoblasts

(Submitter supplied) Adult leg muscle precursors are associated to leg imaginal disc, here we provide bulk RNA sequecing of FACS sorted myoblasts from dissected imaginal leg discs at beginning of pupation.

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19132
6 Samples

Download data: TXT

Series

Accession:: GSE245192

ID:: 200245192

Select item 20021888611.

Nucleoporin Elys attaches peripheral chromatin to the nuclear pores in interphase nuclei

Organism:: Drosophila melanogaster

Type:: Other

Platform:: GPL25244
4 Samples

Download data: MCOOL

Series

Accession:: GSE218886

ID:: 200218886

PubMed Full text in PMC Similar studies

Select item 20021663712.

Molecular Insights into the Inhibition of Proton-Activated Chloride Channel by Transfer RNA

(Submitter supplied) The proton-activated chloride (PAC) channel (also known as acid-sensitive outwardly rectifying anion channel, ASOR) plays a critical role in acid-induced cell death and endocytosis. However, little is known about the regulatory factors and binding partners of PAC. In this study, we discovered that transfer RNA (tRNA) interacts directly with PAC as an unexpected binding partner. Using cryo-electron microscopy, we determined that two PAC trimers and one co-purified tRNA molecule form a stable complex via a highly conserved KR motif, representing the closed conformation. more...

Organism:: Spodoptera frugiperda; Homo sapiens

Type:: Other

Platforms:: GPL18573 GPL27985
2 Samples

Download data: TXT

Series

Accession:: GSE216637

ID:: 200216637

PubMed Similar studies

Select item 20026867413.

The pioneer transcription factor Zelda facilitates the exit from regeneration and restoration of patterning in Drosophila

(Submitter supplied) For a damaged tissue to regenerate, the injured site must repair the wound, proliferate, and restore the correct patterning and cell types. We found that Zelda, a pioneer transcription factor largely known for its role in embryonic zygotic genome activation, is dispensable for normal wing development but crucial for wing disc patterning during regeneration. Impairing Zelda function during disc regeneration resulted in adult wings with a plethora of cell fate errors, affecting the veins, margins, and posterior compartment identity. more...

Organism:: Drosophila melanogaster

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL25244
8 Samples

Download data: BED, BIGWIG, NARROWPEAK

Series

Accession:: GSE268674

ID:: 200268674

PubMed Full text in PMC Similar studies

Select item 20025930314.

Mi-2 and E93 coordinate robust cell cycle exit with terminal differentiation through enhancer decommissioning [RNA-seq]

(Submitter supplied) Many postmitotic tissues coordinate robust cell cycle exit with the progression of terminal differentiation. While the signals involved in initiating cell cycle exit during terminal differentiation for some tissues have been described, less is known about the mechanisms that maintain a stable, non-cycling state. We previously found that chromatin accessibility changes at a subset of rate-limiting cell cycle genes occurs during maintenance of cell cycle exit, suggesting chromatin remodelers may play a key role in maintaining a robust postmitotic state during terminal differentiation. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25244
32 Samples

Download data: BW

Series

Accession:: GSE259303

ID:: 200259303

Select item 20025930215.

Mi-2 and E93 coordinate robust cell cycle exit with terminal differentiation through enhancer decommissioning [ATAC-seq]

Organism:: Drosophila melanogaster

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL25244
20 Samples

Download data: BW

Series

Accession:: GSE259302

ID:: 200259302

Select item 20026994516.

A Vago-like gene enhances dengue and Zika virus dissemination in Aedes aegypti

(Submitter supplied) Arthropod-borne viruses (arboviruses) such as dengue virus (DENV) and Zika virus (ZIKV) pose a significant threat to global health. Novel approaches to control arbovirus spread are focused on harnessing the antiviral immune system of their main vector, the Aedes aegypti mosquito. In arthropods, genes of the Vago family are often presented as analogs of mammalian cytokines with potential antiviral functions, but the role of Vago genes upon virus infection in Ae. more...