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mafaa MAF bZIP transcription factor Aa [ Danio rerio (zebrafish) ]

Gene ID: 100000492, updated on 2-Nov-2024

Summary

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Official Symbol
mafaaprovided by ZNC
Official Full Name
MAF bZIP transcription factor Aaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-010605-3
See related
Ensembl:ENSDARG00000044155 AllianceGenome:ZFIN:ZDB-GENE-010605-3
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mafa; mafl; SMaf1
Summary
Enables sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in myotome; nervous system; neural tube; and somite. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human MAFA (MAF bZIP transcription factor A). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See mafaa in Genome Data Viewer
Location:
chromosome: 6
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (32699363..32703518, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (32714673..32718828, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene KN motif and ankyrin repeat domains 4 Neighboring gene uncharacterized LOC137495884 Neighboring gene zinc finger CCCH-type containing 3 Neighboring gene cylindromatosis (turban tumor syndrome), like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation, characterization, and expression analysis of zebrafish large Mafs. Kajihara M, et al. J Biochem, 2001 Jan. PMID 11134968
  2. Molecular classification of zebrafish retinal ganglion cells links genes to cell types to behavior. Kölsch Y, et al. Neuron, 2021 Feb 17. PMID 33357413, Free PMC Article
  3. Recruitment of Rod Photoreceptors from Short-Wavelength-Sensitive Cones during the Evolution of Nocturnal Vision in Mammals. Kim JW, et al. Dev Cell, 2016 Jun 20. PMID 27326930, Free PMC Article
  4. Phylogenomic analysis and expression patterns of large Maf genes in Xenopus tropicalis provide new insights into the functional evolution of the gene family in osteichthyans. Coolen M, et al. Dev Genes Evol, 2005 Jul. PMID 15759153
  5. Mouse MafA, homologue of zebrafish somite Maf 1, contributes to the specific transcriptional activity through the insulin promoter. Kajihara M, et al. Biochem Biophys Res Commun, 2003 Dec 19. PMID 14680841

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transcription factor MafAa
Names
Transcription factor MafA
somite Maf1
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Aa
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein L
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082940.2 → NP_001076409.1  transcription factor MafAa

    See identical proteins and their annotated locations for NP_001076409.1

    Status: VALIDATED

    Source sequence(s)
    CU694370, EH441535, EH467419
    UniProtKB/Swiss-Prot
    A3KMR8, Q98UK3
    UniProtKB/TrEMBL
    B3DGB3
    Related
    ENSDARP00000064832.4, ENSDART00000064833.5
    Conserved Domains (2) summary
    cd14718
    Location:218 → 287
    bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    pfam08383
    Location:106 → 139
    Maf_N; Maf N-terminal region

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    32699363..32703518 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A3KMR8.1 GenPept UniProtKB/Swiss-Prot:A3KMR8

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