sost sclerostin [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sostprovided by ZNC
Official Full Name: sclerostinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-110411-139
See related: Ensembl:ENSDARG00000061259 AllianceGenome:ZFIN:ZDB-GENE-110411-139
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkeyp-44b3.1
Summary: Predicted to enable BMP binding activity. Predicted to be involved in negative regulation of BMP signaling pathway; negative regulation of Wnt signaling pathway; and ossification. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including Kupffer's vesicle; endochondral bone; nervous system; notochord outer sheath cell; and pharyngeal arch cartilage. Human ortholog(s) of this gene implicated in autosomal dominant craniodiaphyseal dysplasia; sclerosteosis; and sclerosteosis 1. Orthologous to human SOST (sclerostin). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (27331361..27334329)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (27239968..27244296)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Whereas mammalian SOST is expressed almost exclusively by osteocytes, in both medaka and zebrafish (a species with osteocytic bones), SOST is expressed by a variety of nonosteocytic cells, none of which reside within the bone bulk.
Title: A novel nonosteocytic regulatory mechanism of bone modeling.
Sost mRNA was abundantly expressed in the pharyngeal arch cartilage, and in developing pectoral fins of zebrafish.
Title: Expression of sclerostin in the developing zebrafish (Danio rerio) brain and skeleton.

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General gene information

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Markers

fk42e08.x1 (e-PCR)
- UniSTS:201003

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables BMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables heparin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ossification	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sclerostin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

27331361..27334329

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021480342.2 → XP_021336017.1 sclerostin

UniProtKB/TrEMBL

A0A8M9PX42, E7EXX7

Related

ENSDARP00000081642.5, ENSDART00000087208.6

Conserved Domains (1) summary

cl21545
Location:34 → 208

GHB_like; Glycoprotein hormone beta chain homologues

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018394847.1 Reference GRCz11 ALT_DRER_TU_1

Range

250464..253336

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001340647.6 → XP_001340683.2 sclerostin

UniProtKB/TrEMBL

A0A8M1PZF1

Conserved Domains (1) summary

cl21545
Location:34 → 208

GHB_like; Glycoprotein hormone beta chain homologues