ppp1cb protein phosphatase 1, catalytic subunit, beta isozyme [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ppp1cbprovided by ZNC
Official Full Name: protein phosphatase 1, catalytic subunit, beta isozymeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030616-609
See related: Ensembl:ENSDARG00000044153 AllianceGenome:ZFIN:ZDB-GENE-030616-609
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fa09h01; wu:fa11e06; ik:tdsubc_2f2; si:zc214p16.4; xx:tdsubc_2f2
Summary: Enables protein heterodimerization activity. Acts upstream of or within convergent extension involved in axis elongation and liver development. Predicted to be active in cytoplasm and nucleus. Is expressed in intestine and liver. Human ortholog(s) of this gene implicated in Noonan syndrome-like disorder with loose anagen hair 2. Orthologous to human PPP1CB (protein phosphatase 1 catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 17

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (25635950..25649075, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (25617562..25630686, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

zebrafish have two genes encoding PP1beta, both of which can interact with Mypt1
Title: Protein phosphatase 1 β paralogs encode the zebrafish myosin phosphatase catalytic subunit.

Submit: New GeneRIF Correction

General gene information

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Markers

fa09h01.s1 (e-PCR)
- UniSTS:202268

fa11e06.s1 (e-PCR)
- UniSTS:202310

fk82b01.x1 (e-PCR)
- UniSTS:201576

fd58b03.y1 (e-PCR)
- UniSTS:195706

fa11e06.r1 (e-PCR)
- UniSTS:186844

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in circadian regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within convergent extension involved in axis elongation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within convergent extension involved in axis elongation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glycogen metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian rhythm	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine/threonine-protein phosphatase PP1-beta catalytic subunit

Names: plb; ppp1cba

NP_001004527.3

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004527.4 → NP_001004527.3 serine/threonine-protein phosphatase PP1-beta catalytic subunit

Status: VALIDATED

Source sequence(s)

AL929207

UniProtKB/TrEMBL

Q1JPZ8

Related

ENSDARP00000109442.3, ENSDART00000130955.3