med13a mediator complex subunit 13a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: med13aprovided by ZNC
Official Full Name: mediator complex subunit 13aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070627-13
See related: Ensembl:ENSDARG00000053884 AllianceGenome:ZFIN:ZDB-GENE-070627-13
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: med13; thrap1; im:7158513; si:dkeyp-53h3.2
Summary: Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of mediator complex. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human MED13 (mediator complex subunit 13). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (28030042..28117200, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (28143417..28230575, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coregulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of mediator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mediator complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mediator of RNA polymerase II transcription subunit 13a

Names: mediator complex subunit 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001281468.1 → NP_001268397.1 mediator of RNA polymerase II transcription subunit 13a

Status: VALIDATED

Source sequence(s)

BX000486, CR925779

UniProtKB/TrEMBL

A0A8M1P4N9, E7FCQ8

Related

ENSDARP00000083285.4, ENSDART00000088852.6

Conserved Domains (2) summary

pfam06333
Location:1624 → 2144

Med13_C; Mediator complex subunit 13 C-terminal

pfam11597
Location:14 → 384

Med13_N; Mediator complex subunit 13 N-terminal