jam2b junctional adhesion molecule 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: jam2bprovided by ZNC
Official Full Name: junctional adhesion molecule 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-080229-3
See related: Ensembl:ENSDARG00000079071 AllianceGenome:ZFIN:ZDB-GENE-080229-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sc:d0813; im:7155552; si:ch211-160b11.5
Summary: Predicted to be involved in leukocyte cell-cell adhesion. Predicted to be located in membrane. Predicted to be part of protein complex involved in cell adhesion. Predicted to be active in cell surface; plasma membrane; and tight junction. Is expressed in several structures, including epicardium; mesoderm; musculature system; pharyngeal arch; and ventral mesenchyme. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human JAM2 (junctional adhesion molecule 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 9

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (34996245..35009747)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (35187060..35200562)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The developmental expression pattern of jam-b2 suggests that it may contribute different properties to extraocular muscles, jaw muscles, and pectoral fins.
Title: Zebrafish jam-b2 Gal4-enhancer trap line recapitulates endogenous jam-b2 expression in extraocular muscles.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in leukocyte cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protein complex involved in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in tight junction	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: junctional adhesion molecule 2b

Names: jamb2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128294.1 → NP_001121766.1 junctional adhesion molecule 2b precursor

Status: PROVISIONAL

Source sequence(s)

CR936415

UniProtKB/TrEMBL

A0A8M1NH75, B0V233

Related

ENSDARP00000102441.3, ENSDART00000111437.5

Conserved Domains (3) summary

smart00408
Location:154 → 220

IGc2; Immunoglobulin C-2 Type

smart00410
Location:44 → 134

IG_like; Immunoglobulin like

cl11960
Location:44 → 135

Ig; Immunoglobulin domain