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spop speckle type BTB/POZ protein [ Danio rerio (zebrafish) ]

Gene ID: 100005514, updated on 2-Nov-2024

Summary

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Official Symbol
spopprovided by ZNC
Official Full Name
speckle type BTB/POZ proteinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1378
See related
Ensembl:ENSDARG00000100519 AllianceGenome:ZFIN:ZDB-GENE-040426-1378
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
SPOP1; zgc:64140
Summary
Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of proteolysis. Predicted to be located in nuclear speck. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colorectal cancer; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human SPOP (speckle type BTB/POZ protein). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See spop in Genome Data Viewer
Location:
chromosome: 3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (20657843..20793660, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (20508463..20571322, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene nerve growth factor receptor a (TNFR superfamily, member 16) Neighboring gene uncharacterized LOC103910239 Neighboring gene neurexophilin-1 Neighboring gene uncharacterized LOC137490535 Neighboring gene uncharacterized LOC137490537 Neighboring gene NDUFA4 mitochondrial complex associated a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. SPOP mutation leads to genomic instability in prostate cancer. Boysen G, et al. Elife, 2015 Sep 16. PMID 26374986, Free PMC Article
  2. Zebrafish spop promotes ubiquitination and degradation of mavs to suppress antiviral response via the lysosomal pathway. Yu GQ, et al. Int J Biol Macromol, 2024 Jan. PMID 38029910
  3. A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor. Zhang Q, et al. Dev Cell, 2006 Jun. PMID 16740475
  4. Zebrafish rest regulates developmental gene expression but not neurogenesis. Kok FO, et al. Development, 2012 Oct. PMID 22951640, Free PMC Article
  5. Zebrafish Collagen Type I: Molecular and Biochemical Characterization of the Major Structural Protein in Bone and Skin. Gistelinck C, et al. Sci Rep, 2016 Feb 15. PMID 26876635, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC64140, MGC174052

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
speckle-type POZ protein
Names
HIB homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201130.2 → NP_957424.1  speckle-type POZ protein

    See identical proteins and their annotated locations for NP_957424.1

    Status: VALIDATED

    Source sequence(s)
    AL929247, BX248239, BX908767, CU855817
    UniProtKB/Swiss-Prot
    Q7T330
    UniProtKB/TrEMBL
    A7YYH8
    Related
    ENSDARP00000130146.1, ENSDART00000163473.2
    Conserved Domains (3) summary
    cd03774
    Location:28 → 166
    MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...
    cd18518
    Location:297 → 367
    BACK_SPOP; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP)
    cl38908
    Location:179 → 301
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    20657843..20793660 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068215324.1 → XP_068071425.1  speckle-type POZ protein isoform X1

    Related
    ENSDARP00000152225.1, ENSDART00000193532.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7T330.1 GenPept UniProtKB/Swiss-Prot:Q7T330

Gene LinkOut

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