gal galanin/GMAP prepropeptide [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: galprovided by ZNC
Official Full Name: galanin/GMAP prepropeptideprovided by ZNC
Primary source: ZFIN:ZDB-GENE-111117-2
See related: Ensembl:ENSDARG00000091377 AllianceGenome:ZFIN:ZDB-GENE-111117-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ppg; galn
Summary: Predicted to enable galanin receptor activity; galanin receptor binding activity; and neuropeptide hormone activity. Acts upstream of or within response to light stimulus and sleep. Located in neuronal cell body. Is expressed in several structures, including brain; eye; heart; pleuroperitoneal region; and spinal cord. Human ortholog(s) of this gene implicated in familial temporal lobe epilepsy 8. Orthologous to human GAL (galanin and GMAP prepropeptide). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (10556288..10564203, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (10459482..10467848, complement)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Role of Galanin during Bacterial Infection in Larval Zebrafish.
Title: The Role of Galanin during Bacterial Infection in Larval Zebrafish.
Galanin Signaling in the Brain Regulates Color Pattern Formation in Zebrafish.
Title: Galanin Signaling in the Brain Regulates Color Pattern Formation in Zebrafish.
Galn plays a key role in responding to sleep pressure signals derived from neuronal activity and functions as an output arm of the vertebrate sleep homeostat.
Title: The Neuropeptide Galanin Is Required for Homeostatic Rebound Sleep following Increased Neuronal Activity.
Galanin overexpression reduced the incidence of seizure-like behavior episodes and their intensity but had no significant effect on their duration. The findings indicate that in addition to antiepileptic action, galanin modulates arousal behavior and demonstrates a sedative effect. The current study showed that galanin overexpression correlated with a potent anticonvulsant effect in the zebrafish PTZ-seizure model.
Title: Neuroanatomical Localization of Galanin in Zebrafish Telencephalon and Anticonvulsant Effect of Galanin Overexpression.
Prok2-induced sleep in light induces hypothalamic galn expression and requires galn. Light-dependent, Prok2-induced sedation requires prokineticin receptor 2 (prokr2) and is strongly suppressed in galn mutants.
Title: Light-Dependent Regulation of Sleep and Wake States by Prokineticin 2 in Zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables galanin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide hormone activity	ISS Inferred from Sequence or Structural Similarity more info
enables type 1 galanin receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables type 2 galanin receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables type 3 galanin receptor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to light stimulus	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to salt stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sleep	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: galanin peptides

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001346239.1 → NP_001333168.1 galanin peptides preproprotein

Status: VALIDATED

Source sequence(s)

EH455016

UniProtKB/Swiss-Prot

E7EZ53

Related

ENSDARP00000128202.1, ENSDART00000154776.3

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007136.7 Reference GRCz11 Primary Assembly

Range

10556288..10564203 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005162992.5 → XP_005163049.1 galanin peptides isoform X1

UniProtKB/Swiss-Prot

E7EZ53

Related

ENSDARP00000154557.1, ENSDART00000190212.1

Conserved Domains (3) summary

smart00071
Location:21 → 117

Galanin; Galanin

pfam01296
Location:33 → 61

Galanin; Galanin

pfam06540
Location:62 → 114

GMAP; Galanin message associated peptide (GMAP)