a2ml alpha-2-macroglobulin-like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: a2mlprovided by ZNC
Official Full Name: alpha-2-macroglobulin-likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-090212-1
See related: Ensembl:ENSDARG00000056314 AllianceGenome:ZFIN:ZDB-GENE-090212-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within liver development. Predicted to be located in extracellular space. Is expressed in gut; liver; yolk; and yolk syncytial layer. Orthologous to human PZP (PZP alpha-2-macroglobulin like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 15

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (21113969..21132483, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (21178237..21196748, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Two distinct lineages of alpha(2)M and alpha (2) and M-like isoforms exist and at least some codons in the functional domains of alpha(2)M have been subjected to positive Darwinian selection.
Title: Dynamic evolutionary pattern of alpha2-macroglobulin in a model organism, the zebrafish (Danio rerio).
This report on A2ML function in zebrafish development provides the first evidence for a specific role of an A2M family gene in liver formation during early embryogenesis in a vertebrate.
Title: Alpha2 macroglobulin-like is essential for liver development in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fb80a07.x1 (e-PCR)
- UniSTS:191522

AA497347 (e-PCR)
- UniSTS:206929

fd43e10.x1 (e-PCR)
- UniSTS:195449

fc48d09.y1 (e-PCR)
- UniSTS:193984

fb66f01.x1 (e-PCR)
- UniSTS:190936

fc90g08.x1 (e-PCR)
- UniSTS:194789

aa497267 (e-PCR)
- UniSTS:186869

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha-2-macroglobulin-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001139479.2 → NP_001132951.1 alpha-2-macroglobulin-like precursor

See identical proteins and their annotated locations for NP_001132951.1

Status: VALIDATED

Source sequence(s)

CR626907

UniProtKB/TrEMBL

A0A8M9QPQ0, B8QSI4

Related

ENSDARP00000073195.4, ENSDART00000078734.6

Conserved Domains (6) summary

cd02897
Location:948 → 1234

A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...

pfam00207
Location:729 → 817

A2M; Alpha-2-macroglobulin family

pfam01835
Location:127 → 218

A2M_N; MG2 domain

pfam07677
Location:1341 → 1431

A2M_recep; A-macroglobulin receptor

pfam07678
Location:1000 → 1236

A2M_comp; A-macroglobulin complement component

pfam07703
Location:466 → 607

A2M_N_2; Alpha-2-macroglobulin family N-terminal region