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slc7a8a solute carrier family 7 member 8a [ Danio rerio (zebrafish) ]

Gene ID: 100007704, updated on 2-Nov-2024

Summary

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Official Symbol
slc7a8aprovided by ZNC
Official Full Name
solute carrier family 7 member 8aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-121120-2
See related
Ensembl:ENSDARG00000075831 AllianceGenome:ZFIN:ZDB-GENE-121120-2
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable L-amino acid transmembrane transporter activity and neutral L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport and neutral amino acid transport. Predicted to act upstream of or within amino acid transport and transmembrane transport. Predicted to be located in basolateral plasma membrane and lateral plasma membrane. Orthologous to human SLC7A8 (solute carrier family 7 member 8). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See slc7a8a in Genome Data Viewer
Location:
chromosome: 7
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (24210086..24236282, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (23938929..23965125, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene guanosine monophosphate reductase 2 Neighboring gene NEDD8 ubiquitin like modifier Neighboring gene sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 Neighboring gene thioredoxin b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Automated detection and quantification of single RNAs at cellular resolution in zebrafish embryos. Stapel LC, et al. Development, 2016 Feb 1. PMID 26700682
  2. Leucine/glutamine and v-ATPase/lysosomal acidification via mTORC1 activation are required for position-dependent regeneration. Takayama K, et al. Sci Rep, 2018 May 29. PMID 29844341, Free PMC Article
  3. Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison. Walter KM, et al. PLoS One, 2019. PMID 31513589, Free PMC Article
  4. Effects of thyroid hormone disruption on the ontogenetic expression of thyroid hormone signaling genes in developing zebrafish (Danio rerio). Walter KM, et al. Gen Comp Endocrinol, 2019 Feb 1. PMID 30448381, Free PMC Article
  5. Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates. Szenker-Ravi E, et al. Nat Genet, 2022 Jan. PMID 34903892

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables neutral L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in neutral amino acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 7 member 8a
Names
solute carrier family 7 (amino acid transporter light chain, L system), member 8a
solute carrier family 7 (cationic amino acid transporter, y+ system), member 8a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271897.1 → NP_001258826.1  solute carrier family 7 member 8a

    Status: VALIDATED

    Source sequence(s)
    CR318603
    UniProtKB/TrEMBL
    A0A8M1P532, E7EXU6
    Related
    ENSDARP00000012295.8, ENSDART00000010124.10
    Conserved Domains (1) summary
    TIGR00911
    Location:1 → 497
    2A0308; L-type amino acid transporter

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    24210086..24236282 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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