Fancf Fanconi anemia, complementation group F [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fancfprovided by MGI
Official Full Name: Fanconi anemia, complementation group Fprovided by MGI
Primary source: MGI:MGI:3689889
See related: Ensembl:ENSMUSG00000092118 AllianceGenome:MGI:3689889
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A730016A17
Summary: Contributes to ubiquitin protein ligase activity. Acts upstream of or within several processes, including ovarian follicle development; protein ubiquitination; and spermatogenesis. Part of Fanconi anaemia nuclear complex. Used to study primary ovarian insufficiency. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group F; adenocarcinoma in situ; and granulosa cell tumor. Orthologous to human FANCF (FA complementation group F). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human all
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Genomic context

Location:: 7 B4; 7 32.87 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (51510325..51512015, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (51860577..51862267, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our results suggest that FANCF suppresses ovarian tumourigenesis through its role in normal gonadal development, but also by maintaining genome stability
Title: Fancf-deficient mice are prone to develop ovarian tumours.
Data identify the gene encoding Fanconi F (FANCF) as an ICSBP target gene.
Title: The interferon consensus sequence binding protein (ICSBP/IRF8) activates transcription of the FANCF gene during myeloid differentiation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to ubiquitin protein ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interstrand cross-link repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Fanconi anaemia nuclear complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Fanconi anaemia nuclear complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of Fanconi anaemia nuclear complex	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: Fanconi anemia group F protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001115087.1 → NP_001108559.1 Fanconi anemia group F protein

Status: VALIDATED

Source sequence(s)

AC158345

Consensus CDS

CCDS52261.1

UniProtKB/Swiss-Prot

E9Q5Z5

Related

ENSMUSP00000125812.2, ENSMUST00000169357.2

Conserved Domains (1) summary

pfam11107
Location:1 → 333

FANCF; Fanconi anemia group F protein (FANCF)