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Tcp10c t-complex protein 10c [ Mus musculus (house mouse) ]

Gene ID: 100041352, updated on 9-Aug-2024

Summary

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Official Symbol
Tcp10cprovided by MGI
Official Full Name
t-complex protein 10cprovided by MGI
Primary source
MGI:MGI:98543
See related
Ensembl:ENSMUSG00000052469 AllianceGenome:MGI:98543
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm9880; T66C-a; Tcp-10c; D17Leh66C; D17Leh66ca
Summary
Predicted to enable several functions, including identical protein binding activity; protein self-association; and transcription corepressor activity. Predicted to be active in centriole and nucleus. Orthologous to several human genes including TCP10L (t-complex 10 like) and TCP10L2 (t-complex 10 like 2, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 144.4) See more
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Genomic context

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See Tcp10c in Genome Data Viewer
Location:
17 8.86 cM; 17 A1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (13574834..13597485)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (13354572..13377223)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 31, D17Leh66c region Neighboring gene predicted gene, 36537 Neighboring gene tubulin tyrosine ligase-like family, member 2 pseudogene Neighboring gene predicted gene, 25730

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An unstable family of large DNA elements in the center of the mouse t complex. Schimenti J, et al. J Mol Biol, 1987 Apr 20. PMID 2821263
  2. Molecular clones of the mouse t complex derived from microdissected metaphase chromosomes. Röhme D, et al. Cell, 1984 Mar. PMID 6697397
  3. Sequence of the t complex Tcp-10at gene and examination of the Tcp-10t gene family. Davies PO, et al. Mamm Genome, 1991. PMID 1794052
  4. A candidate gene family for the mouse t complex responder (Tcr) locus responsible for haploid effects on sperm function. Schimenti J, et al. Cell, 1988 Oct 7. PMID 3167978
  5. Molecular cloning and genetic mapping of the t complex responder candidate gene family. Bullard DC, et al. Genetics, 1990 Apr. PMID 2323558, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
t-complex protein 10c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167578.1 → NP_001161050.1  t-complex protein 10c

    Status: VALIDATED

    Source sequence(s)
    AC166110, AK076614, CJ046593
    Consensus CDS
    CCDS49953.1
    UniProtKB/TrEMBL
    E9Q046, Q8C641
    Related
    ENSMUSP00000095015.4, ENSMUST00000097403.4
    Conserved Domains (2) summary
    cl21524
    Location:17 → 111
    PRK13923; putative spore coat protein regulator protein YlbO; Provisional
    pfam07202
    Location:308 → 480
    Tcp10_C; T-complex protein 10 C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    13574834..13597485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523280.3 → XP_006523343.1  t-complex protein 10c isoform X4

    UniProtKB/TrEMBL
    Q8C641
    Conserved Domains (1) summary
    pfam07202
    Location:341 → 514
    Tcp10_C; T-complex protein 10 C-terminus

  2. XM_006523277.3 → XP_006523340.1  t-complex protein 10c isoform X1

    Conserved Domains (1) summary
    pfam07202
    Location:401 → 574
    Tcp10_C; T-complex protein 10 C-terminus

  3. XM_006523278.4 → XP_006523341.1  t-complex protein 10c isoform X2

    UniProtKB/TrEMBL
    Q8C641
    Conserved Domains (2) summary
    cl21524
    Location:77 → 171
    PRK13923; putative spore coat protein regulator protein YlbO; Provisional
    pfam07202
    Location:368 → 541
    Tcp10_C; T-complex protein 10 C-terminus

  4. XM_006523279.3 → XP_006523342.1  t-complex protein 10c isoform X3

    UniProtKB/TrEMBL
    B2RUN1
    Conserved Domains (1) summary
    pfam07202
    Location:348 → 521
    Tcp10_C; T-complex protein 10 C-terminus

  5. XM_006523281.4 → XP_006523344.1  t-complex protein 10c isoform X5

    UniProtKB/TrEMBL
    Q8C641
    Conserved Domains (2) summary
    cl21524
    Location:77 → 171
    PRK13923; putative spore coat protein regulator protein YlbO; Provisional
    pfam07202
    Location:315 → 488
    Tcp10_C; T-complex protein 10 C-terminus
Nucleotide Protein Strain
Heading Accession and Version

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