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Alyreffm10 Aly/REF export factor family member 10 [ Mus musculus (house mouse) ]

Gene ID: 100043292, updated on 9-Dec-2024

Summary

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Official Symbol
Alyreffm10provided by MGI
Official Full Name
Aly/REF export factor family member 10provided by MGI
Primary source
MGI:MGI:3782524
See related
Ensembl:ENSMUSG00000090854 AllianceGenome:MGI:3782524
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm4340
Summary
Predicted to enable C5-methylcytidine-containing RNA reader activity and mRNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to be located in cytoplasm. Predicted to be part of catalytic step 2 spliceosome; exon-exon junction complex; and transcription export complex. Predicted to be active in nucleus. Predicted to colocalize with chromosome, telomeric region. Orthologous to human ALYREF (Aly/REF export factor). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Alyreffm10 in Genome Data Viewer
Location:
10 D1; 10 54.72 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (104029903..104032383)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (104194042..104196522)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene Aly/REF export factor family member 17 Neighboring gene Aly/REF export factor family member 15 Neighboring gene predicted gene, 22339 Neighboring gene microRNA 6411

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables C5-methylcytidine-containing RNA reader activity ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of exon-exon junction complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription export complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RNA and export factor-binding protein 2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177535.1 → NP_001171006.1  RNA and export factor-binding protein 2-like

    See identical proteins and their annotated locations for NP_001171006.1

    Status: VALIDATED

    Source sequence(s)
    AC141428
    Consensus CDS
    CCDS88081.1
    UniProtKB/TrEMBL
    M0QWS9
    Related
    ENSMUSP00000137824.4, ENSMUST00000181615.8
    Conserved Domains (3) summary
    COG0724
    Location:79 → 186
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12680
    Location:86 → 160
    RRM_THOC4; RNA recognition motif in THO complex subunit 4 (THOC4) and similar proteins
    pfam07078
    Location:6 → 59
    FYTT; Forty-two-three protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    104029903..104032383
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313746.1 → XP_017169235.1  RNA and export factor-binding protein 2-like isoform X1

    UniProtKB/TrEMBL
    M0QWB2, M0QWR4
    Conserved Domains (3) summary
    cd12680
    Location:86 → 160
    RRM_THOC4; RNA recognition motif in THO complex subunit 4 (THOC4) and similar proteins
    TIGR01648
    Location:26 → 179
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    pfam13865
    Location:169 → 230
    FoP_duplication; C-terminal duplication domain of Friend of PRMT1

  2. XM_030244788.1 → XP_030100648.1  RNA and export factor-binding protein 2-like isoform X2

    UniProtKB/TrEMBL
    M0QWB2, M0QWR4
    Conserved Domains (3) summary
    cd12680
    Location:86 → 160
    RRM_THOC4; RNA recognition motif in THO complex subunit 4 (THOC4) and similar proteins
    TIGR01648
    Location:26 → 179
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    pfam13865
    Location:169 → 229
    FoP_duplication; C-terminal duplication domain of Friend of PRMT1
Nucleotide Protein
Heading Accession and Version

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